Results 201 to 210 of about 14,941,622 (355)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Treatment strategies, complications, and outcomes in spontaneous cerebellar hemorrhage: a swedish observational single-center study. [PDF]

Acta Neurochir (Wien)
Sida H, Kevci R, Velle F, Lewén A, Fahlström A, Enblad P, Svedung Wettervik T.   +6 more
europepmc   +1 more source

Measuring Outcome [PDF]

Journal of the Royal Society of Medicine, 1985
openaire   +2 more sources

Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort.

The Lancet Diabetes and Endocrinology, 2017
T. Williams, J. Lenders, P. Mulatero, J. Burrello, M. Rottenkolber, C. Adolf, F. Satoh, L. Amar, M. Quinkler, J. Deinum, F. Beuschlein, K. K. Kitamoto, U. Pham, R. Morimoto, H. Umakoshi, A. Prejbisz, T. Kocjan, M. Naruse, M. Stowasser, T. Nishikawa, W. Young, C. Gomez-Sanchez, J. Funder, M. Reincke   +23 more
semanticscholar   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Magnesium intake and sleep symptoms: Findings from the Jiangsu Nutrition Cohort Study of Chinese adults

Journal of Nutrition & Intermediary Metabolism, 2017
Y. Cao, A.W. Taylor, R. Adams, S. Appleton, Z. Shi   +4 more
doaj   +1 more source

Connectivity Predicts deep brain stimulation outcome in Parkinson disease

Annals of Neurology, 2017
A. Horn, M. Reich, J. Vorwerk, Ningfei Li, G. Wenzel, Qianqian Fang, T. Schmitz-Hübsch, R. Nickl, A. Kupsch, J. Volkmann, A. Kühn, M. Fox   +11 more
semanticscholar   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Development of a CORe outcome set for clinical trials of RECTal cancer treatment: protocol for the CORRECT initiative. [PDF]

BMJ Open
Garfinkle R, George M, Jethwa K, Johansen P, Lakaszawski M, Nagarajan A, Smart N, Sylla P, Vuong T, Boutros M, Fergusson DA.   +10 more
europepmc   +1 more source