Results 231 to 240 of about 8,864,759 (285)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Controversies and challenges in outcome measurement for skull base surgery: A cross-pathology analysis. [PDF]

Surg Neurol Int
Abboud RS, Sviri GE.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Association between on-scene cardiopulmonary resuscitation duration and outcomes in out-of-hospital cardiac arrest patients. [PDF]

World J Emerg Med
Chun S, Woon Kim G, Bit Kim H.
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Association between agonal breathing and outcomes after out-of-hospital cardiac arrest: a retrospective study. [PDF]

J Am Coll Emerg Physicians Open
Taniguchi H, Yamada K, Kitano S, Bunya N, Homma Y, Tagami T, Aoki M, SOS-KANTO 2017 Study Group.   +7 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

A parsimonious nomogram for individualized prediction of 1-year functional outcome after STN-DBS in Parkinson's disease: a single-center retrospective study. [PDF]

Front Neurol
Zhang Y, Zhu Q, Fang B, Geng F.
europepmc   +1 more source

Association between sustained moderate hyperglycemia within first 48 hours and poor functional outcome after polytrauma: A retrospective cohort study. [PDF]

Eur J Trauma Emerg Surg
Deininger MM, Wassersteiner P, Haehn N, Huth J, Marx G, Weber CD, Hildebrand F, Simon TP, Benstoem C, Breuer T.   +9 more
europepmc   +1 more source