Results 231 to 240 of about 14,971,001 (334)

Interictal SEEG Resting‐State Connectivity Localizes the Seizure Onset Zone and Predicts Seizure Outcome

, 2022
Haiteng Jiang, Vasileios Kokkinos, Shuai Ye, Alexandra Urban, Anto Bagić, Mark P. Richardson, Bin He   +6 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Applying machine learning to enhance core outcome set development: automating the data extraction and classification of outcomes. [PDF]

J Orthop Surg Res
Yalcinkaya A, Kjelmann KG, Gholinezhad S, Rahbek O, Kold S, Husum HC.   +5 more
europepmc   +1 more source

Protease Inhibitors and Cardiovascular Outcomes in Patients With HIV and Heart Failure

, 2018
Raza M. Alvi, Anne M. Neilan, Noor Tariq, Magid Awadalla, Maryam Afshar, Dahlia Banerji, Adam Rokicki, Connor P. Mulligan, Virginia A. Triant, Markella V. Zanni, Tomas G. Neilan   +10 more
openalex   +2 more sources

Dissecting maternal and fetal genetic effects underlying the associations between maternal phenotypes, birth outcomes, and adult phenotypes: A mendelian-randomization and haplotype-based genetic score analysis in 10,734 mother–infant pairs

, 2020
Jing Chen, Jonas Bačelis, Pol Solé-Navais, Amit Kumar Srivastava, Julius Juodakis, Amy Rouse, Mikko Hallman, Kari Teramo, Mads Melbye, Bjarke Feenstra, Rachel M. Freathy, George Davey Smith, Debbie A. Lawlor, Jeffrey C. Murray, Scott M. Williams, Bo Jacobsson, Louis J. Muglia, Ge Zhang   +17 more
openalex   +1 more source

Perinatal health outcomes of East African immigrant populations in Victoria, Australia: a population based study [PDF]

, 2016
Fetene B. Belihu, Mary‐Ann Davey, Rhonda Small   +2 more
openalex   +1 more source

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

Environmental Toxicology and Chemistry, 2010
G. Ankley, R. S. Bennett, R. Erickson, Dale J. Hoff, M. W. Hornung, Rodney D. Johnson, D. Mount, J. Nichols, C. Russom, P. Schmieder, Jose A. Serrrano, J. Tietge, D. Villeneuve   +12 more
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The gynecologic tumor risk related to GLP-1 receptor agonists and SGLT2 inhibitors use: a network meta-analysis of 91 randomized controlled trials. [PDF]

J Hematol Oncol
Tseng PT, Zeng BY, Hsu CW, Sun CK, Suen MW, Carvalho AF, Stubbs B, Chen YW, Chen TY, Lei WT, Chen PH, Chen JJ, Shiue YL, Zeng BS, Su KP, Liang CS.   +15 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source