Results 261 to 270 of about 14,941,622 (355)

Serum microbiome-related metabolites-including short-chain fatty acids and indole derivatives-predict outcome and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: a two-timepoint LC-MS study. [PDF]

Front Neurol
Nagybanyai-Nagy B, Tengölics R, Sajben C, Olasz D, Schwarcz A, Molnar T, Csecsei P.   +6 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Treatment outcomes and long-term relapse-free survival after multidrug-resistant tuberculosis treatment in Latvia: a retrospective national cohort study. [PDF]

Lancet Reg Health Eur
Meier SC, Kukša L, Ķauķe S, Riekstina V, Biraua E, Jain N, Lange C, Brehm TT.   +7 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Using Propensity Score Weighting With Clustered Data When the Treatment Is Applied at the Level of the Cluster and Outcomes Are Assessed at the Level of the Individual: The Observational Analog of Cluster Randomization Trials. [PDF]

Stat Med
Austin PC.
europepmc   +1 more source

Early Versus Later Anticoagulation for Acute Ischemic Stroke in Patients With Atrial Fibrillation: A Systematic Review and Meta-Analysis. [PDF]

J Arrhythm
Ahmad MN, Waheed A, Gandhi NM, Rayamajhi S, Alsayed MA, Banerjee S, de Lima Loiola JA, Yousuf HM, Udo EB, Bista M, Cheema HA, Alsubari AMA, Khan MU, Nadeem B, Vats V.   +14 more
europepmc   +1 more source

Outcome predictors in older adults (≥ 65 years) with aneurysmal subarachnoid haemorrhage. [PDF]

Neurosurg Rev
Kehoe L, Borg D, Corr P, Nolan D, Coffey D, Amoo M, Nicholson P, Javadpour M.   +7 more
europepmc   +1 more source