Results 301 to 310 of about 14,055,650 (415)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Pavlovian to instrumental transfer of control over fight or flight decisions. [PDF]

NPJ Sci Learn
Eder AB, Mitschke V.
europepmc   +1 more source

IMPACTED CERUMEN AURIS MANAGEMENT: COMPARISON OF OUTCOME BETWEEN SUCTION CLEARANCE AND SYRINGING

, 1969
Muhammad Ismail Khan, Mahid Iqbal, Muhammad Muhammad   +2 more
openalex   +2 more sources

Can a Shift in Fuel Energetics Explain the Beneficial Cardiorenal Outcomes in the EMPA-REG OUTCOME Study? A Unifying Hypothesis

Diabetes Care, 2016
S. Mudaliar, Sindura K. Alloju, R. Henry
semanticscholar   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Rapidity of hematoma resolution after fibrinolytic therapy for intracerebral hemorrhage has a favorable effect on functional outcome. [PDF]

Sci Rep
Malinova V, Schwiddessen R, von der Brelie C, Mielke D, Rohde V.   +4 more
europepmc   +1 more source

OUTCOME OF THE MILLARD ROTATION- ADVANCEMENT PROCEDURE FOR THE UNILATERAL CLEFT LIP IN TWO HOSPITALS OF BANNU

, 1969
Hayat Ur Rehman, Mehnaz Khattak, Muhammad Imran, MAHID IQBAL, M JEHANGIR KHAN   +4 more
openalex   +2 more sources

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

To Implement or Not to Implement? A Commentary on the Pitfalls of Judging the Value and Risks of Personalized Prognostic Statistical Models.

J Med Internet Res
Baumbach L, Hötzendorfer W, Baumbach J.
europepmc   +1 more source

Which outcomes should be included in a core outcome set for capturing and measuring doctor well-being? A Delphi study. [PDF]

BMJ Open
Simons G, Klepacz N, Baldwin DS.
europepmc   +1 more source