Results 341 to 350 of about 14,055,650 (415)

Can subordinate performance simultaneously reduce leader ostracism and promote leader recognition? A moderated mediation model. [PDF]

Front Psychol
Xu Q, Huang H, Zhang X, Zhao S, Zhou L.
europepmc   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Cerebral perfusion pressure targets after traumatic brain injury: a reappraisal. [PDF]

Crit Care
Bögli SY, Olakorede I, Beqiri E, Chen X, Lavinio A, Hutchinson P, Smielewski P.   +6 more
europepmc   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Anaesthetic Techniques for Cardiac Ablation-A Scoping Review Protocol. [PDF]

Acta Anaesthesiol Scand
Fredensborg MB, Fiege SB, Møller AM.
europepmc   +1 more source

ADVERSE NEURODEVELOPMENTAL OUTCOME OF MODERATE NEONATAL HYPOGLYCEMIA [PDF]

, 1988
COLE, TJ, LUCAS, A, MORLEY, R
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Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Design, analysis, and reporting of pilot and feasibility trials in anesthesiology: a methodological study. [PDF]

Pilot Feasibility Stud
Atkin-Jones T, Ali M, Eze-Onuorah ACJ, Ifeanacho E, Khosravirad A, Madden K, Sadeghirad B, Mbuagbaw L.   +7 more
europepmc   +1 more source

Outcome of Judicial Review Jobcentre Plus referrals [PDF]

, 2012

core