Results 351 to 360 of about 14,055,650 (415)

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Prognostic value of lymphocyte-to-monocyte ratio in acute ischemic stroke: a systematic review and meta-analysis. [PDF]

Front Neurol
Tian C, Yang Y, Wan J, Wang R, Zhou K, Li Y, Guo W, Li H, Zhang Y.   +8 more
europepmc   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Call to action for genetic counseling research in hereditary cancer: Considerations from the evidence-based guidelines development process. [PDF]

J Genet Couns
Levin B, Salo-Mullen E, Culver JO, Kurz RN, Brock P, Demsky R, Lloyd S, Lopez G, Mai PL, Wolfe Schneider K.   +9 more
europepmc   +1 more source

Bidirectional mendelian randomization assessment of causality between lactate levels and multiple autoimmune diseases. [PDF]

Sci Rep
Fan H, Song H, Fu Q, Du G, Bai Y, Zhang C, Shi X.   +6 more
europepmc   +1 more source

Slowing fetal growth velocity from the mid-trimester may signal increased risks of perinatal morbidity and mortality: a retrospective cohort study. [PDF]

BMC Med
Jamieson-Grigg C, Kalinowski P, Tong S, Turner E, Banting SA, Walker SP, MacDonald TM.   +6 more
europepmc   +1 more source

Heterogeneity of Treatment Outcomes Across Therapists and Sites in a Randomized Multicentre Psychotherapy Trial. [PDF]

Clin Psychol Psychother
Petter J, Schumacher L, Echterhoff J, Klein JP, Schramm E, Härter M, Hautzinger M, Kriston L.   +7 more
europepmc   +1 more source

Profiling 92 circulating neurobiological proteins identifies novel candidate biomarkers of long-term cognitive outcome after ischemic stroke. [PDF]

Sci Rep
Lagging C, Pedersen A, Petzold M, Furutjäll S, Samuelsson H, Jood K, Stanne TM, Jern C.   +7 more
europepmc   +1 more source

Prognostic Utility of F-Waves in Paraplegic Dogs With Absent Pain Perception Secondary to Intervertebral Disc Extrusion. [PDF]

J Vet Intern Med
Togawa G, Lewis MJ, Were SR, Bentley RT, Thomovsky SA.   +4 more
europepmc   +1 more source