Results 71 to 80 of about 9,615,173 (340)

Costs of treatment of haemophilia A in Italy: comparison of the use of plasma-derived and recombinant FVIII using a discrete event simulation (DES) model

Farmeconomia: Health Economics and Therapeutic Pathways, 2013
OBJECTIVE: To simulate haemophilia A (HA) real-life management and compare the cost of different treatment strategies, both with plasma-derived and recombinant factor VIII (pdFVIII and rFVIII, respectively), from the perspective of the Italian NHS ...
Mario Eandi, Lorenzo Pradelli, Massimiliano Povero   +2 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Identification region of the potential outcome distributions under instrument independence [PDF]

, 2009
This paper examines identification power of the instrument exogeneity assumption in the treatment effect model. We derive the identification region: The set of potential outcome distributions that are compatible with data and the model restriction.
Kitagawa, T.
core  

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

A meta-analysis of the relation between therapeutic alliance and treatment outcome in eating disorders. [PDF]

, 2017
The therapeutic alliance has demonstrated an association with favorable psychotherapeutic outcomes in the treatment of eating disorders (EDs). However, questions remain about the inter-relationships between early alliance, early symptom improvement, and ...
Antoniou, Bachelor, Bedics, Borenstein, Bourion-Bedes, Bravender, Brown, Brown, Card, Cohen, Cohen, Constantino, Cooper, Crits-Christoph, DeRubeis, Egger, Ellison, Fassino, Fassino, Flückiger, Flückiger, Forsberg, Hartmann, Hildebrandt, Horvath, Isserlin, Jones, Karver, Le Grange, Lipsey, Lock, Loeb, Mander, Manlick, Margraf, Martin, McLeod, Miller, Mitchell, Morlino, Munsch, Paulson Karlsson, Prestano, Raykos, Shirk, Simpson, Sly, Sly, Sperry, Stiles-Shields, Strober, Tang, Tasca, Tasca, Tasca, Thomas, Thompson-Brenner, Treasure, Vitousek, Vocks, Waller, Westwood, Wilson, Wilson, Zaitsoff, Zeeck   +65 more
core   +3 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

An update on domineering on rectangular boards [PDF]

, 2013
Domineering is a combinatorial game played on a subset of a rectangular grid between two players. Each board position can be put into one of four outcome classes based on who the winner will be if both players play optimally.
Drummond-Cole, Gabriel C.
core   +1 more source

Diagnosis and outcome of oesophageal Crohn's disease [PDF]

, 2019
BACKGROUND AND AIMS: Crohn's disease (CD) can involve any part of the gastrointestinal tract. We aimed to characterize clinical, endoscopic, histologic features and treatment outcomes of CD patients with oesophageal involvement.
Beaton, D, Chaparro, M, Ellul, P, Katsanos, K, Oliveira, AM, et al., Rodrigues, R, Savarino, E, Sladek, M, Teich, N, van der Woude, J, Vavricka, R, Wei, J   +11 more
core   +1 more source

The Relationship between Alcohol Consumption and other Risk Factors Assessed Using An Ongoing Population-based Surveillance System

AIMS Public Health, 2016
The aim of this study was to determine the relationship of alcohol consumption (reported in four different ways) with other specific disease-related risk factors (that is, smoking, high body mass index, low physical activity and insufficient fruit and ...
Anne W Taylor, Zumin Shi, Eleonora Dal Grande, Creina Stockley   +3 more
doaj   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source