Results 121 to 130 of about 797,426 (292)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Assessment Indicators as a Tool of Process Monitoring, Benchmarking and Learning Outcomes Assessment: Features of Two Types Indicators

, 2016
Soichiro Aihara
openalex   +2 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Supply of Inputs and Procedures Non-Invasive and Micro-Invasive in Primary Care: Historical Series by Brazilian Regions

Pesquisa Brasileira em Odontopediatria e Clínica Integrada
Objective: To analyze the supply of input and procedures, non-invasive and micro-invasive, for dental caries lesions in Primary Care in Brazil, comparing the Brazilian geographic regions in three different periods. Material and Methods: Historical series
Manoelito Ferreira Silva-Junior, Larissa Yumi Ito, Letícia Simeoni Avais, Letícia Plocharski, Natália Almeida Bastos-Bitencourt, Ana Cláudia Rodrigues Chibinski, Alessandra de Souza Martins   +6 more
doaj  

Assessment of psychotherapy process and outcome: a review [PDF]

, 2009
Ana Carolina Peuker, Luísa Fernanda Habigzang, Sílvia Helena Koller, Lisiane Bizarro   +3 more
openalex  

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Avaliação da qualidade de assistência primária à saúde em localidade urbana da região sul do Brasil

Revista de Saúde Pública
Foi estudada transversalmente uma amostra de 10% dos pacientes que consultaram em dois Postos de Assistência Primária à Saúde da Cidade de Pelotas (RS), Brasil, com o objetivo de avaliar, qualitativamente, o cuidado à saúde que estava sendo oferecido ...
Iná S. Halal, Felipe Sparrenberger, Anete M. Bertoni, Carla Ciacomet, Carlos E. Seibel, Flávia M. Lahude, Gilson A. Magalhães, Lirio Barreto, Rita C.A. Lira   +8 more
doaj  

The value of co-creating a clinical outcome assessment strategy for clinical trial research: process and lessons learnt [PDF]

, 2023
Thomas Morel, Karlin Schroeder, Sophie Cleanthous, John Andrejack, Geraldine Blavat, William S. Brooks, Lesley Gosden, Carroll Siu, Natasha Ratcliffe, Ashley F. Slagle   +9 more
openalex   +1 more source

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source