Results 81 to 90 of about 970,201 (218)

Revolutionizing Nursing Education in Somalia: Recommendations for Integrating AI and Deep Learning in Outcome Based Assessments to Enhance Knowledge, Practice, and Graduate Competence. [PDF]

J Multidiscip Healthc
Yusuf FY, Hussein AM.
europepmc   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

EU-HTA-Why Do Words Matter? [PDF]

J Mark Access Health Policy
Toumi M, Falissard B, Simoens S, Postma M, Wilk M, Boyer L, Bernardini R, Capri S, Espin J, Wasem J, Auquier P.   +10 more
europepmc   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

AI-assisted thematic synthesis of existing neurological core outcome sets: A descriptive reference framework (COS-Neuro). [PDF]

PLoS One
Tiong SP, Yang X, Touzet AY, Millward CP, Zipser CM, Tetreault L, Gharooni A, Davies BM.   +7 more
europepmc   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Clinical trials in neurosciences: Need for standards for innovation on clinical outcomes. [PDF]

Neurosci Appl
Zaragoza Domingo S, Pinkham A, Tinoco D, Kottner J, Balabanov P, Butlen-Ducuing F, Bury-Maynard D, Outcomes Research in Neurosciences & ECNP Network Clinical Outcomes in Early-Phase Clinical Trials groups.   +7 more
europepmc   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Effects of different telehabilitation methods on postoperative pulmonary rehabilitation of patients with lung cancer: a systematic review and network meta-analysis of randomised controlled trials protocol. [PDF]

BMJ Open
Liu J, Niu H, Li J, Chen Q, Bi H.
europepmc   +1 more source