Results 151 to 160 of about 549,947 (276)

Curing the blood and balancing life: Understanding, impact and health seeking behaviour following stroke in Central Aceh, Indonesia

, 2009
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Previous studies have highlighted the importance of understanding the subjective illness experience.
Norris, Meriel
core  

Through Mintzberg’s glasses: a fresh look at the organization of ministries of health

Bulletin of the World Health Organization, 2000
In 1987, district health care policies were officially adopted by a majority of developing countries. Many operational problems constraining implementation of such policies have subsequently been identified, most of which are attributable to well-known ...
Jean-Pierre Unger, Jean Macq, François Bredo, Marleen Boelaert   +3 more
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Developing a Core Outcome Measurement Set for Adult ICU Patients, the CoreMS-ICU-A Protocol. [PDF]

Acta Anaesthesiol Scand
Kjær MN, Bruun CRL, Mortensen CB, Schandl A, Haines K, Hofsø K, Blokzijl F, Granholm A, Møller MH, Tøgern A, Rasmussen BS, Poulsen LM, Strøm T, Laerkner E, Brøchner AC, Haberlandt T, Bunzel AG, Herløv LS, Holm A, Sivapalan P, Estrup S, Cronhjort M, Laake JH, Pfortmueller CA, Ostermann M, Cole JM, Wise MP, Wludarczyk A, Szczeklik W, Jovaiša T, Cecconi M, Sigurdsson MI, Nalos M, Hästbacka J, Mäkinen M, Dye J, Hammond N, Litton E, Keus F, Myatra SN, Vijayaraghavan BKT, Yadav K, Venkatesh B, Egerod I, Larsen RF, Needham DM, Rose L, Connolly B, Spies C, Hodgson C, Munblit D, Gorst S, Perner A, Collet MO.   +53 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Management of hypertension in mental health patients in a primary care setting : an assessment of quality of care

, 2009
Includes summary.Includes bibliographical references (leaves 44-48).In his experience working in the Metro District Health Services Clinics of the Department of Western Cape, the researcher has encountered numerous cases of sub-standard quality of ...
Motsohi, Tsepo
core  

Family or caregiver outcomes after critical illness (FOCUS): a protocol for a core outcome set development study. [PDF]

BMJ Open
Brown C, Hartley P, Malyon A, Connolly B, Lone NI, McPeake J.   +5 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

A stakeholder derived framework for safety assessment in the NHS case management programme [PDF]

Patient safety measurement methods are dominated by outcome measurement, reducing them to counts of harm or adverse events. Performance measurement recognises the limitations of the sole use of outcome indicators and proposes the use of measures ...
Jones, Sarahjane
core