Results 181 to 190 of about 547,962 (228)

Natural language processing to enhance rheumatoid arthritis care in clinical studies: a scoping review of applications, data, approaches, challenges and future directions. [PDF]

Rheumatol Int
Huang Y, Agarwal SK.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Development of a core screening, assessment and outcome set for cancer prehabilitation: an international Delphi consensus study protocol. [PDF]

BMJ Open
Parkington T, Humphreys LJ, West M, Myers A, Keen C, Denehy L, Gillis C, Edbrooke L, Moore J, Steffens D, Bongers BC, Slooter GD, Nile K, Garner N, Copeland R, National Cancer Prehabilitation Coll The Royal Marsden Cancer Charity.   +15 more
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Integrated Digital Decision-Making Systems in Maternal Nursing and Maternity Care: A Scoping Review. [PDF]

J Multidiscip Healthc
Darmayanti D, Widiasih R, Hadi S, Solehati T.   +3 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Mindfulness-Based Psychoeducation App to Improve the Well-Being of Parents and Caregivers of Children With Autism: Development and Usability Study. [PDF]

JMIR Pediatr Parent
Ma KKY, Chan SSM, Wong EWY, Choi O, Mo FYM, Shea CKS, Ho CSW, Leung PWL, So SHW, Bögels SM, Ng FFY, Chau SWH, Lai KYC, Fung GPC, Wong OWH.   +14 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

The components and effects of home rehabilitation on activities of daily living and physical performance of community dwelling older people with low physical performance - a systematic review and meta-analysis of randomized controlled trials. [PDF]

BMC Geriatr
Högstedt K, Grooten WJA, Flink M, Baudin K, Guidetti S, Rydwik E.   +5 more
europepmc   +1 more source