Results 31 to 40 of about 448,893 (233)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

The qualitative dimension of Nursing workload: a measurement proposal

Revista Latino-Americana de Enfermagem, 2019
Objective: construct and test a proposal to measure the qualitative dimension of nursing workload; identify the workload cut-off point and its indicator as predictors of the good and optimal nursing care product score.
Danielle Fabiana Cucolo, Marcia Galan Perroca   +1 more
doaj   +3 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Big Data-Planetary Health approach for evaluating the Brazilian Dengue Control Program

Revista de Saúde Pública
OBJECTIVE This study aims to integrate the concepts of planetary health and big data into the Donabedian model to evaluate the Brazilian dengue control program in the state of São Paulo.
Fernando Xavier, Gerson Laurindo Barbosa, Cristiano Corrêa de Azevedo Marques, Antonio Mauro Saraiva   +3 more
doaj   +2 more sources

Structure and work process in primary care and hospitalizations for sensitive conditions

Revista de Saúde Pública, 2017
OBJECTIVE The objective of this study is to investigate whether the characteristics of the structure of primary health units and the work process of primary care teams are associated with the number of hospitalizations for primary care sensitive ...
Waleska Regina Machado Araujo, Rejane Christine de Sousa Queiroz, Thiago Augusto Hernandes Rocha, Núbia Cristina da Silva, Elaine Thumé, Elaine Tomasi, Luiz Augusto Facchini, Erika Barbara Abreu Fonseca Thomaz   +7 more
doaj   +1 more source

Establishing Inter-Rater Reliability of the Occupation-Centered Intervention Assessment for Student Observation of Rehabilitation Interventions

Journal of Occupational Therapy Education, 2021
The Occupation-Centered Intervention Assessment (OCIA) is a tool designed to capture and rank occupational therapy interventions through an occupational lens to improve occupational therapy students’ professional reasoning skills.
Vanessa D. Jewell, Joy Burkley, Taylor Wienkes, Ted K. Kaufman   +3 more
doaj   +1 more source

Do it fast! Early access to specialized care improved long-term outcomes in rheumatoid arthritis: data from the REAL multicenter observational study

Advances in Rheumatology, 2023
Background Early rheumatoid arthritis (RA) offers an opportunity for better treatment outcomes. In real-life settings, grasping this opportunity might depend on access to specialized care.
Cleandro Pires Albuquerque, Ana Paula Monteiro Gomides Reis, Ana Beatriz Vargas Santos, Manoel Barros Bértolo, Paulo Louzada Júnior, Rina Dalva Neubarth Giorgi, Sebastião Cezar Radominski, Maria Fernanda B. Resende Guimarães, Karina Rossi Bonfiglioli, Maria de Fátima L Cunha Sauma, Ivânio Alves Pereira, Claiton Viegas Brenol, Licia Maria Henrique Mota, Leopoldo Santos-Neto, Geraldo Rocha Castelar Pinheiro   +14 more
doaj   +1 more source

Breast cancer screening program for risk groups: facts and perspectives

Revista Brasileira de Enfermagem, 2021
Objectives: to measure the frequency and compliance of breast cancer screening, according to the risk for this disease. Methods: a cross-sectional study with 950 female users of 38 public Primary Health Care services in São Paulo, between October and ...
Carla Andréia Vilanova Marques, Elisabeth Níglio de Figueiredo, Maria Gaby Rivero de Gutiérrez   +2 more
doaj   +2 more sources