Results 41 to 50 of about 448,893 (233)

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Preventive and therapeutic assessment program for mucositis in patients with cancer: promising advances in stomatological care

Brazilian Journal of Oncology
OBJECTIVES: We propose a preventive and therapeutic assessment program for mucositis in patients with cancer based on a comprehensive review of scientific evidence. MATERIAL AND METHODS: This methodological study, designed as a non-systematic
Renata Lemos Ferrari, Rafaela Mota Peixoto, Tauana Batista Fernandes, Luana Farnese Machado Abreu, Ana Carolina de Araujo Tolentino Felizardo, Lourenço Duarte Siqueira, Ana Maria Dias da Costa, Bianca Silva de Andrade, Clara de Figueiredo Lopes, Daniele Ferreira Araujo, Leticia Fulgencio de Araújo, Ruan Soares da Silva, Flavia Santos Dumont Sorice, Sarah Ananda Gomes, Bruno Lemos Ferrari, Carlos Gil Moreira Ferreira, Mariana Tosello Laloni, Pedro Rafael Martins De-Marchi, Cristiane Decat Bergerot   +18 more
doaj   +1 more source

Development of a Quality Management Model and Self-assessment Questionnaire for Hybrid Health Care: Concept Mapping Study

JMIR Formative Research, 2022
BackgroundWorking with eHealth requires health care organizations to make structural changes in the way they work. Organizational structure and process must be adjusted to provide high-quality care. This study is a follow-up study
Rosian Tossaint-Schoenmakers, Marise J Kasteleyn, Anneloek Rauwerdink, Niels Chavannes, Sofie Willems, Esther P W A Talboom-Kamp   +5 more
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Patient Assessment Chronic Illness Care (PACIC) and its associations with quality of life among Swiss patients with systemic sclerosis: a mixed methods study

Orphanet Journal of Rare Diseases, 2023
Background The Chronic Care Model (CCM) is a longstanding and widely adopted model guiding chronic illness management. Little is known about how CCM elements are implemented in rare disease care or how patients’ care experiences relate to health-related ...
Agnes Kocher, Michael Simon, Andrew A. Dwyer, Catherine Blatter, Jasmina Bogdanovic, Patrizia Künzler-Heule, Peter M. Villiger, Diana Dan, Oliver Distler, Ulrich A. Walker, Dunja Nicca   +10 more
doaj   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

Assessing the adherence to and the therapeutic effectiveness of hypolipidemic agents in a population of patients in Brazil: a retrospective cohort study

Pharmacy Practice, 2014
Objective: to evaluate the relation between patient adherence and therapeutic effectiveness of hypolipidemic agents in clinical practice. Methods: A retrospective cohort study of 417 patients using hypolipidemic drugs (simvastatin, atorvastatin) between
Cunico C, Picheth G, Correr CJ, Scartezini M   +3 more
doaj  

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Avaliação do processo da atenção médica: adequação do tratamento de pacientes com diabetes mellitus, Pelotas, Rio Grande do Sul, Brasil

Cadernos de Saúde Pública
Com objetivo de avaliar a adequação do manejo de pacientes diabéticos, durante o ano de 1998 foram entrevistados, em domicílio, pacientes atendidos nos postos de saúde da zona urbana de Pelotas, Rio Grande do Sul, Brasil.
Maria Cecília Formoso Assunção, Iná da Silva dos Santos, Juvenal Soares Dias da Costa   +2 more
doaj   +2 more sources