Results 101 to 110 of about 12,158,807 (343)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Treatment options for patients with pilonidal sinus disease: PITSTOP, a mixed-methods evaluation

Health Technology Assessment
Background There is no consensus on optimal management of pilonidal disease. Surgical practice is varied, and existing literature is mainly single-centre cohort studies of varied disease severity, interventions and outcome assessments.
Steven Brown, Daniel Hind, Emily Strong, Mike Bradburn, Farhat Vanessa Nasim Din, Ellen Lee, Matthew J Lee, Jonathan Lund, Christine Moffatt, Jonathan Morton, Asha Senapati, Philip Shackley, Peter Vaughan-Shaw, Arkadiusz Peter Wysocki, Tia Callaghan, Helen Jones, Nyantara Wickramasekera   +16 more
doaj   +1 more source

P29.05: The value of cerebroplacental ratio assessment for the prediction of obstetrical outcome in term appropriate‐for‐gestational age fetuses [PDF]

, 2016
I. Cataneo, G. Salsi, Federica Bellussi, N. Rizzo, G. Pilu, A. Youssef   +5 more
openalex   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Trainee involvement increases precut rates and delays access to the common bile duct without an increase in procedure-related adverse events: a brave new world of ERCP training?

Romanian Journal of Internal Medicine, 2018
Background and aims. Selective cannulation of the desired duct is a key element in ERCP procedures and an important step in the training of fellows.
Voiosu Theodor, Voiosu Andrei, Benguş Andreea, Rimbaş Mihai, Mateescu Bogdan   +4 more
doaj   +1 more source

Exploring the use of continuous assessment in the context of outcome-based education in Malawian primary schools

, 2021
Colby Hetherwick Kumwenda, Wezzie Chiziwa   +1 more
openalex   +1 more source

Contextualizing the outcome of a maturity assessment for Industry 4.0

, 2018
The transformation of the manufacturing sector towards Industry 4.0 is setting the scene for a major industrial change. Currently, the need for assisting companies in this transformation is covered by a number of maturity models that assess their digital
Michele Colli, O. Madsen, U. Berger, Charles Møller, B. Wæhrens, Markus Thomas Bockholt   +5 more
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source