Results 201 to 210 of about 12,158,807 (343)

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

Environmental Toxicology and Chemistry, 2010
G. Ankley, R. S. Bennett, R. Erickson, Dale J. Hoff, M. W. Hornung, Rodney D. Johnson, D. Mount, J. Nichols, C. Russom, P. Schmieder, Jose A. Serrrano, J. Tietge, D. Villeneuve   +12 more
semanticscholar   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

A pilot study: Incorporating <i>Treponema pallidum</i> antigens into machine learning models for accurate syphilis treatment outcome assessment. [PDF]

iScience
Yao J, Deng D, Yu H, Duan J, Xia S, Cao X, Xie Y, Xie B, Ling P, Zhao F.   +9 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Traditional Chinese medicine for non-alcoholic fatty liver disease: an overview of systematic reviews with evidence mapping and metabolic outcome assessment. [PDF]

Front Pharmacol
Li J, Jiao R, Su W, Chen W, Hu X, Xu S, Xu L, Yao W, Liu K, You H, Zhao J.   +10 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Applications of Artificial Intelligence in Oral and Maxillofacial Cosmetic Surgery: A Systematic Review of Diagnostic, Planning, and Outcome Assessment Tools. [PDF]

Cureus
Abdali HM, Ayoub AY, Omer RA, Alanazi RA, Alsaedi BS, Almutairi LB, Alhakami BA, Alfifa AY, Alnasser NA, Hakami AH.   +9 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Development of a novel clinical outcome assessment: digital instrumental activities of daily living. [PDF]

EBioMedicine
Sawyer A, Brannigan J, Spielman L, BCI Functional Outcome Measures Group, Putrino D, Fry A.   +5 more
europepmc   +1 more source

Impact Assessment of Community Solar Gardens on Lighting and Health Outcomes in South African Villages,

, 2001
Nkosihla Maseko
openalex   +1 more source