Results 211 to 220 of about 2,110,249 (346)

Patient acceptability and usability of a self-administered electronic patient-reported outcome assessment in HIV care: relationship with health behaviors and outcomes

, 2020
Rob J. Fredericksen, Barbara N Harding, Stephanie A. Ruderman, Liz Morton, G. Barnes, William B. Lober, Emma Fitzsimmons, Robin M. Nance, Bridget M. Whitney, Joseph A. Delaney, William C. Mathews, James H. Willig, Paul K. Crane, Heidi M. Crane   +13 more
openalex   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Outcomes of guidelines from health technology assessment organizations in community-based primary care: a systematic mixed studies review [PDF]

Ashkan Baradaran, Raymond Tolentino, Roland Grad, Isabelle Ganache, Geneviève Gore, Samira Abbasgholizadeh Rahimi, Pierre Pluye   +6 more
openalex   +1 more source

Assessment of mental health outcomes and associated factors among workers in community-based HIV care centers in the early stage of the COVID-19 outbreak in Mali

, 2020
Luis Sagaon‐Teyssier, Aliou Kamissoko, Adam Yattassaye, Fodié Diallo, Daniela Rojas Castro, Rosemary M. Delabre, Fabrice Pouradier, Gwenaëlle Maradan, Michel Bourrelly, Mamadou Cissé, Laurent Vidal, Bintou Dembélé Keïta, Bruno Spire   +12 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

A guided chatbot-based psychological intervention for psychologically distressed older adolescents and young adults: a randomised clinical trial in Jordan. [PDF]

NPJ Digit Med
Bryant RA, de Graaff AM, Habashneh R, Fanatseh S, Keyan D, Akhtar A, Abualhaija A, Faroun M, Aqel IS, Dardas L, Afar H, Servili C, Hadzi-Pavlovic D, van Ommeren M, Carswell K.   +14 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source