Results 81 to 90 of about 1,570,153 (247)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Modulation of the brain activity in outcome evaluation by the presence of an audience: An electrophysiological investigation

, 2015
The audience effect refers to the phenomenon that one's performance on a task is affected by the presence of others. Here we investigated how the audience effect modulates the neurocognitive signatures underlying people's evaluation of their own ...
Wang, Lili, Guan, Qing, Gu, Ruolei, Feng, Chunliang, Feng, Xue, Tian, Tengxiang, Broster, Lucas S., Luo, Yue-Jia   +7 more
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Evaluation in Japan

, 2005
Two years have passed since the “Government Policy Evaluations Act” (GPEA) became effective in Japan on April 1, 2002. In that time, evaluation has been well accepted as an essential part of the policy management cycle at each ministry of the Japanese ...
Ryo Sasaki, Sasaki, Ryo, Ryoh Sasaki
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Women's empowerment in South Africa: Evaluation of the Raising Her Voice project

, 2017
This evaluation is presented as part of the Effectiveness Review Series 2015/16, selected for review under the women’s empowerment thematic area.
Stedman-Bryce, Gavin
core  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Outcome Evaluation of StartBiz

, 2017
Part 7: EvaluationInternational audienceThe following paper presents the results of the outcome evaluation of StartBiz; an online tool for start-ups in Switzerland.
Zimmermann, Philippe, Kristina Zumbusch, Philippe Zimmermann, Zumbusch, Kristina, Fohim, Emamdeen, Emamdeen Fohim   +5 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Outcome evaluation in pediatric orthopedics

, 2014
Outcome evaluation is an objective procedure to determine the impact and success of a therapeutic program, focusing on the patient's well being in daily life. It is important not to confuse the different concepts found in the health status classification
Viehweger, E., Jouve, J.-L., Simeoni, M.-C.   +2 more
core   +1 more source