Results 201 to 210 of about 28,929 (254)

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

The "I" in egalitarianism: Hadza hunter-gatherers averse to inequality primarily when personally unfavorable. [PDF]

PNAS Nexus
Smith KM, Stibbard Hawkes DNE, Dimant E, Mabulla IA, Bicchieri C, Apicella CL.   +5 more
europepmc   +1 more source

Endogenous Amplification of Apoptosis via p53 Regulation using a Cascade Nanocatalytic Medicine

Advanced Science, EarlyView.
An engineered MOF nanomedicine (MAL) triggers cascade nanocatalysis in tumors, converting H2O2 and L‐Arg into cytotoxic peroxynitrite. This induces DNA damage, activates the p53 pathway, and amplifies mitochondrial apoptosis via the BAX/Bcl‐2/Caspase‐3 axis, effectively inhibiting colorectal cancer growth with high biocompatibility.
Tan Wu, Xiaoyue Xu, Dan Xu, Hui Zhang, Nan Wang, Yang Yang, Qian Chen, Shunjie Chen, Cheng Li   +8 more
wiley   +1 more source

AI-driven gamification and metacognitive strategy development: a study of primary school English vocabulary learning from a self-regulated learning perspective. [PDF]

Front Psychol
Wu H, Wang X.
europepmc   +1 more source

Asymmetric Cu─N─Ru Bridgedsite Nanozyme‐Loaded Injectable Thermogel Boosts Cuproptosis‐Like Death for Multidrug‐Resistant Urinary Tract Infections

Advanced Science, EarlyView.
To address multidrug‐resistant urinary tract infections (MDR‐UTIs), we developed Cu‐ZIF8‐Ru nanozyme featuring an asymmetric Cu─N─Ru catalytic site. This unique structure enhances multienzyme‐mimetic activity, eradicating resistant bacteria by inducing a cuproptosis‐like death pathway through intracellular Cu2+ accumulation and energy depletion.
Guanlin Li, Shike Zhang, Jinggong Liu, Xin Wang, Heng Wang, Hongcan Yang, Yuhao Zhou, Wen Liu, Hongxing Liu, Wenqi Wu   +9 more
wiley   +1 more source

Interfacial Synergy in a Band‐Aligned Low‐Dimensional Heterojunction Toward Broadband Photodetection

Advanced Science, EarlyView.
Monolithically integrating sensing and communication, a Ta2NiSe5/Sb2Te3 heterojunction achieves visible‐to‐near‐infrared photovoltaics with high‐speed terahertz photo‐thermoelectric detection at room temperature. By engineering a Type‐II van der Waals heterojunction, we overcome the intrinsic spectral limitations and disparate physical requirements of ...
Yuanfeng Wen, Kening Xiao, Yao Yang, Mengjie Jiang, Libo Zhang, Shicong Hou, Hang Ma, Yunduo Zhang, Wenqi Mo, Yiran Tan, Bolang Peng, Jinqiu Huang, Xueyuan Wei, Chunming Liu, Bangjian Zhao, Jiale He, Qing Li, Songyuan Ding, Yi Zhou, Guanhai Li, Xiaoshuang Chen   +20 more
wiley   +1 more source

Assessing and managing the suicidal patient: forget the Reverend Bayes and try game theory. [PDF]

BJPsych Bull
Nielssen O.
europepmc   +1 more source

Using a Multicomponent Implementation Strategy to Increase Adoption and Effectiveness of a Universal Mental Health Prevention Program in Australian Primary Schools: a Cluster Randomized Trial Using a Type-3 Hybrid Design. [PDF]

Prev Sci
Baffsky R, Wong QJJ, Cullen P, Werner-Seidler A, Calear AL, Batterham PJ, Toumbourou JW, McGillivray L, O'Dea B, Ivers R, Torok M.   +10 more
europepmc   +1 more source

Pricing Incentive Mechanisms for Medical Data Sharing in the Internet of Things: A Three-Party Stackelberg Game Approach. [PDF]

Sensors (Basel)
Zhu D, Zhou Z, Zhang H, Chen Y, Li Y, Zheng J.   +5 more
europepmc   +1 more source

Perceptual rationality: an evolutionary game theory of perceptually rational decision-making. [PDF]

R Soc Open Sci
Salahshour M.
europepmc   +1 more source