Results 201 to 210 of about 334,200 (306)

Diagnosis, Prognosis, and Drug Target Discovery for Chronic Widespread Pain: A Large Proteogenomic Study

Advanced Science, EarlyView.
Plasma proteomics is leveraged to decode the biological underpinnings of chronic widespread pain. A nested machine learning framework integrates proteomic signatures, prospective outcomes, and Mendelian randomization to uncover 18 causal proteins.
Li Chen, Eoin Kelleher, Ruogu Meng, Duanke Liu, Yuchen Guo, Yunhe Wang, Yaqing Gao, Zhe Huang, Zhu Liang, Shuai Yuan, Chao Zeng, Jun Ma, Yanhui Dong, Anushka Irani, Guanghua Lei, Junqing Xie, Daniel Prieto‐Alhambra   +16 more
wiley   +1 more source

Investigation of physical education classroom teaching using AHP with IV-CIFS-based aggregation operators. [PDF]

Sci Rep
Zhang W.
europepmc   +1 more source

Peptide Electrostatic Modulation Directs Human Neural Cell Fate

Advanced Science, EarlyView.
This study explores the effect of charge on the bioactivity of peptide‐based supramolecular materials. The design of a peptide library with varying charges that self‐assemble into supramolecular fibers is presented, demonstrating how the surface charge of these fibers, used as artificial extracellular matrices, influences the fate of human neural ...
Laura Perez‐Chirinos, Xavier Barceló, M. Gabriella Chiariello, Irene Sanz, Amaia Iturrospe, Arantxa Arbe, J. Alberto Ortega, Siewert J. Marrink, Aitziber L. Cortajarena, Zaida Álvarez, Ivan R. Sasselli   +10 more
wiley   +1 more source

Play to learn: innovating embryology education through a web-based gamification platform, and evaluating its effects on medical students' reaction, learning, and behavior. [PDF]

BMC Med Educ
Rahimipour M, Haghjoo R, Mosalanejad L, Karimian Z.   +3 more
europepmc   +1 more source

Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing

Advanced Science, EarlyView.
The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.
Lu Huang, Xinran Ye, Chia‐Kang Ho, Ya Gao, Dongsheng Wen, Jiaming Sun, Yuxin Liu, Yangdan Liu, Guoyuan Wang, Yangbai Sun, Jinyan Zhang, Yifan Zhang, Qingfeng Li   +12 more
wiley   +1 more source

Lignin‐Containing Nanocellulose Mediated Interlayer Modulation Unlocks Stable and Redispersible MXene

Advanced Science, EarlyView.
Amphiphilic lignin‐containing nanocellulose (LNC) establishes competitive interactions between MXene nanosheets, enabling precise modulation of interlayer spacing and interfacial chemistry. This strategy allows rapid fabrication of semi‐solid MXene via industrial‐scale spray drying, achieving long‐term reversible redispersibility and exceptional ...
Shuyang He, Zhen Yu, Shan Li, Shijie Lei, Lin Zhu, Ke Zhao, Fangxia Yang, Ningning Cao, Yuyan Liu, Zhimin Fan   +9 more
wiley   +1 more source

Unveiling the nexus of the relationship between multiplayer digital game-playing experience and workplace loneliness: a moderated serial mediation analysis. [PDF]

BMC Psychol
Akgün AE, Keskin H, Esen E, Aksoy Z.
europepmc   +1 more source

Active Learning‐Assisted Exploration of [PO40Mo12]3− for Alzheimer's Therapy Insights

Advanced Science, EarlyView.
Bayesian Optimization coupled with active learning to uncover the interaction mechanism of [PO40Mo12]3− on amyloid‐β peptide. Abstract Alzheimer's disease (AD), involving amyloid‐β (Aβ) aggregation, has potential therapeutic modulators in polyoxometalates (POMs) like [PMo12O40]3−.
Lincan Fang, Ruoxue Peng, Luping Xia, Gui‐lin Zhuang   +3 more
wiley   +1 more source

Neurodevelopmental disorders: assessing and training working memory. [PDF]

BMC Psychol
Ferreira P, David C, Costescu C, Vera L, Herrera G, Lopes S, Stilwell D, Ferreira A, Domingues D, Brito J, Campos J, Paiva AM, Simão AMV, Heldal I, Stefanut T, Rosan A, Trindade F.   +16 more
europepmc   +1 more source

Neural Response Reliability as a Marker of the Transition of Neural Codes along Auditory Pathways

Advanced Science, EarlyView.
Decoding sound from neural activity in mice reveals a striking shift in how the brain encodes sound: from precise but redundant timing codes in early auditory areas to efficient, synergistic rate‐based codes in the cortex. This transformation highlights a robust neural strategy for turning complex acoustic input into coherent perception across the ...
Alexa Buck, Typhaine Dupont, Rupert Andrews Cavanagh, Olivier Postal, Jérôme Bourien, Jean‐Luc Puel, Nicolas Michalski, Boris Gourévitch   +7 more
wiley   +1 more source