Results 41 to 50 of about 622,682 (291)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Employing Game theory and Multilevel Analysis to Predict the Factors that affect Collaborative Learning Outcomes: An Empirical Study

CoRR, 2016
The purpose of this study is to propose a model that predicts the social and psychological factors that affect the individuals collaborative learning outcome in group projects. The model is established on the basis of two theories, namely, the multilevel analysis and the cooperative game theory (CGT).
Sara Taraman, Yasmin Hassan, Doaa Shawky, Ashraf H. Badawi   +3 more
openaire   +2 more sources

Improvement of Mathematics Learning Outcomes by Applying The Missouri Mathematics Project Learning Model And Dienes Game Theory

Mathematics Education Journal, 2020
Based on the results of first observations and interviews with class teachers at SMP Negeri 06 Batu, mathematics learning outcomes for class VIIA students in the End Semester Test (EST) even semester of the 2018/2019 school year had an average grade below the Minimum Criteria of Mastery Learning (MCML) and only about 5 students reached MCML.
Muhammad Fakhri, Marhan Taufik, Agung Deddiliawan Ismail   +2 more
openaire   +3 more sources

Games for Enhancing Sustainability of Year 7 Maths Classes in Indonesia: Theory-Driven Development, Testing and Analyses of Lessons, and of Students' Outcomes [PDF]

Journal on Mathematics Education, 2013
The results of international comparative studies have shown that relationships exist between metacognition and cognitive activation and learning success. Since 2007 we have been carrying out projects in Indonesia to improve cognitive and metacognitive activities of pupils of year 7 and their teachers.
Christa Kaune, Edyta Nowinska, Annika Paetau, Mathilda Griep   +3 more
openaire   +1 more source

A New Mathematical Model for Evolutionary Games on Finite Networks of Players [PDF]

, 2013
A new mathematical model for evolutionary games on graphs is proposed to extend the classical replicator equation to finite populations of players organized on a network with generic topology.
Madeo, Dario, Mocenni, Chiara
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Preschool children fail primate prosocial game because of attentional task demands. [PDF]

PLoS ONE, 2013
Various nonhuman primate species have been tested with prosocial games (i.e. derivates from dictator games) in order to better understand the evolutionary origin of proactive prosociality in humans. Results of these efforts are mixed, and it is difficult
Judith Maria Burkart, Katja Rueth
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Time Scales in Evolutionary Dynamics [PDF]

, 2006
Evolutionary game theory has traditionally assumed that all individuals in a population interact with each other between reproduction events. We show that eliminating this restriction by explicitly considering the time scales of interaction and selection
Cuesta, José A., Pérez Roca, Carlos, Sánchez, Angel   +2 more
core   +4 more sources