Results 171 to 180 of about 15,903,898 (384)

Targeting outcomes redux [PDF]

open access: yes
"...There are sharply divergent views as to how much narrowly targeted interventions actually benefit the poor. These result from differing assessments of three issues: whether better targeting outcomes are likely to be achieved, whether such methods are
Coady, David P.   +2 more
core  

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

Healthcare Costs and Resource Use Among Chronic Low-Back Pain Patients Treated With Belbuca or Buprenorphine Transdermal Patches: A Retrospective US Medicare Claims Analysis

open access: yesPain Research and Management
Conclusion: This study demonstrated lower total cLBP-related and any-cause outpatient costs with fewer cLBP-related outpatient visits and favorable healthcare cost trends in Belbuca as compared with buprenorphine patch patients.
Vladimir Zah   +3 more
doaj   +1 more source

On Outcomes and Humility

open access: yesAcademic Medicine, 2008
Abstract The competency movement in medical education asserts itself in every corner of students’ experiences from matriculation through residency. Such a focus on making sure trainees achieve desired levels of skills, knowledge, and technique is highly desired by the patients they will be servicing, but educators ...
openaire   +4 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

open access: yesFEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona   +4 more
wiley   +1 more source

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes.

open access: yesNew England Journal of Medicine, 2015
B. Zinman   +11 more
semanticscholar   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

open access: yesMolecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia   +17 more
wiley   +1 more source

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