Results 271 to 280 of about 16,988,510 (382)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Alternative Measures of Body Composition and Outcomes Following Heart Transplant. [PDF]

Clin Transplant
Lanier A, Siddiqi U, Siddiqi U, Lee L, Saffari SE, Belkin M, Grinstein J, Kanelidis A, Gozdecki L, Swat S, Kalantari S, Sarswat N, Chung BB, Kim G, Salerno C, Jeevanandam V, Kanwar M, Nguyen A.   +17 more
europepmc   +1 more source

Description of outcomes, patient experiences and related costs of care in low back pain patients undergoing chiropractic treatment in the UK

, 2013
Taco A.W. Houweling
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The Effect of Evening Technology Use on Objective Sleep in Older Adults: Protocol for a Crossover Randomized Controlled Trial.

JMIR Res Protoc
Ghazi SN, Behrens A, Niklasson J, Sanmartin Berglund J, Anderberg P.   +4 more
europepmc   +1 more source

Outcomes from institutional audit: programme specifications [PDF]

, 2005

core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Racial Disparities in Traffic Stop Outcomes [PDF]

, 2017
Baumgartner, Frank R., Christiani, Leah, Epp, Derek A., Roach, Kevin, Shoub, Kelsey   +4 more
core   +1 more source