Results 101 to 110 of about 752,005 (304)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Der LeGeDe-Prototyp: Zur Erstellung eines korpusbasierten Online-Wörterbuchs zu lexikalischen Besonderheiten im gesprochenen Deutsch. Aktueller Stand und Perspektiven

Lexikos, 2020
The LeGeDe-prototype: The Creation of an Online Dictionary on Lexical Particularities in Spoken German. Current Status and Perspectives. The article focuses on the LeGeDe third-party funded project and the corpus-based lexicographic prototype on the ...
Meike Meliss, Christine Möhrs
doaj   +1 more source

The access structure in learner's dictionaries [PDF]

, 2004
CITATION: Steyn, M. 2004. The access structure in learner's dictionaries. Lexikos, 14:275-298, doi:10.5788/14-0-694.The original publication is available at http://lexikos.journals.ac.zaDictionaries have to be compiled in accordance with specific target ...
Steyn, Mariza
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Structural and Functional Insights into the Pilotin-Secretin Complex of the Type II Secretion System

, 2012
PMCID: PMC3276575This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Rehman Saima, Shuang Gu (184317), Rehman, S., Richard W Pickersgill, Pickersgill, R. W., Gu, S, Gu, S., Shuang Gu, Shevchik Vladimir E., Shevchik, V. E., Shevchik, VE, Pickersgill, RW, Wang, X., Wang, X, Vladimir E Shevchik, Xiaohui Wang (19899), Xiaohui Wang, Rehman, S, Vladimir E. Shevchik (184325), Gu Shuang, Pickersgill Richard W., Saima Rehman (184320), Richard W. Pickersgill (87514), Shevchik, Vladimir, Saima Rehman, Wang Xiaohui   +25 more
core   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Structure and inhibition mechanisms of Mycobacterium tuberculosis essential transporter efflux protein A

Nature Communications
A broad chemical genetic screen in Mycobacterium tuberculosis (Mtb) identified compounds (BRD-8000.3 and BRD-9327) that inhibit the essential efflux pump EfpA.
Nitesh Kumar Khandelwal, Meghna Gupta, James E. Gomez, Sulyman Barkho, Ziqiang Guan, Ashley Y. Eng, Tomohiko Kawate, Sree Ganesh Balasubramani, Andrej Sali, Deborah T. Hung, Robert M. Stroud   +10 more
doaj   +1 more source

Structural basis of RND-type multidrug exporters

Frontiers in Microbiology, 2015
Bacterial multidrug exporters are intrinsic membrane transporters that act as cellular self-defense mechanism. The most notable characteristics of multidrug exporters is that they export a wide range of drugs and toxic compounds.
Akihito eYamaguchi, Ryosuke eNakashima, Keisuke eSakurai   +2 more
doaj   +1 more source

Ro60 and Y RNAs: Structure, Functions and Roles in Autoimmunity

Critical reviews in biochemistry and molecular biology, 2019
Ro60, also known as SS-A or TROVE2, is an evolutionarily conserved RNA-binding protein that is found in most animal cells, approximately 5% of sequenced prokaryotic genomes and some archaea.
M. Boccitto, S. Wolin
semanticscholar   +1 more source

Structural and functional studies of bacterial outer membrane lipopolysaccharide insertion and Schmallenberg virus replication

, 2015
Lipopolysaccharide (LPS) is an essential component of the outer membrane (OM) of Gram-negative bacteria and plays a fundamental role in protecting the bacteria from harsh environments and toxic compounds.
Dong, Haohao
core