Results 181 to 190 of about 163,240 (292)

Mechanisms of Mitochondrial Toxicity and Cytotoxicity Caused by Pseudomonas aeruginosa Pyocyanin in Human Nasal Epithelial Cells

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Pseudomonas aeruginosa is an opportunistic pathogen in cystic fibrosis‐related chronic rhinosinusitis (CF‐CRS) that produces phenazine metabolites pyocyanin and 1‐hydroxyphenazine (1‐HP), which may have detrimental effects on mitochondria, reactive oxygen species (ROS), Ca2+ signaling, and apoptosis.
Joel C. Thompson, April Park, Yobouet Ines Kouakou, Zoey A. Miller, Nabil F. Darwich, Nithin D. Adappa, James N. Palmer, Ryan M. Carey, Robert J. Lee   +8 more
wiley   +1 more source

Reconfiguration of Multiphase Coacervate Droplets Into Self‐Regulated Nested Artificial Cells

Angewandte Chemie, EarlyView.
Living cells advance functionality through spatiotemporal sub‐compartmentalization and internal organization. Herein, we develop a self‐regulated artificial cell by transforming a membrane‐less multiphase coacervate droplet (MCD) into a membranized, structurally reinforced nested coacervate vesicle (NCV).
Zhuping Yin, Rui Sun, Jingxin Shao, Jan C. M. van Hest, Stephen Mann   +4 more
wiley   +2 more sources

The Role of Bacterial Outer Membrane Vesicles in Tumor Development: Facts, Potential Applications and Future Perspectives. [PDF]

Int J Nanomedicine
Gu Z, Zhang M, Shen F, Chen J, Gu Y, Gong Y, Xue Q, Zhou H, Liu Y, Shao S, Zhang Y, Bai J, Hua K, Zhou G, Ding J.   +14 more
europepmc   +1 more source

Tree shrew model of early diabetic retinopathy reveals microvascular dysfunction and identifies phosphoserine aminotransferase 1 as a novel therapeutic target

Animal Models and Experimental Medicine, EarlyView.
We developed an animal model of early diabetic retinopathy (DR) in the tree shrew by feeding a high‐fat and high‐sugar diet in combination with STZ. Physiological and biochemical index detection, hematoxylin and eosin staining, and transmission electron microscopy were performed to examine DR.
Min Qiu, Shurui Huo, Wenguang Wang, Na Li, Qingwei Zeng, Xiaomei Sun, Jiejie Dai, Pinfen Tong, Yuanyuan Han, Ling Zhao, Caixia Lu   +10 more
wiley   +1 more source

Correction to "Outer Membrane Vesicles from Caulobacter crescentus: A Platform for Recombinant Antigen Presentation". [PDF]

ACS Nano
Ginez LD, Osorio A, Correal-Medina V, Arenas T, González-Espinosa C, Camarena L, Poggio S.   +6 more
europepmc   +1 more source

Small vesicles, big potential: A review of innovative exosome delivery and molecular mechanisms in preclinical myocardial infarction models

Animal Models and Experimental Medicine, EarlyView.
This narrative review discusses animal models of exosome‐based myocardial infarction treatments. Emerging techniques aim to improve exosome stability, targeting, and bioavailability for MI treatment as drug delivery vehicles and regenerative mediators that promote myocardial regeneration. Abstract Exosomes have emerged as promising therapeutic carriers,
Chayanisa Phutiyothin, Kovit Pattanapanyasat, Sarawut Kumphune   +2 more
wiley   +1 more source

Outer membrane vesicles of carbapenem-resistant <i>Acinetobacter baumannii</i> derive an enhanced inflammatory response. [PDF]

Microbiol Spectr
Yang Y, Tang N, Zeng Y, Zhu J, Li J, Gu L, Wang J, Liu Z, Huang J-a.   +8 more
europepmc   +1 more source

Astrocytic Mitochondria Transplantation Rescues Neuron Loss and Dendritic Injuries in Acute Cerebral Ischemic Stroke Mouse Model by Flexibly Regulating Mitochondria Dynamics

Annals of Neurology, EarlyView.
Objective Cerebral ischemic stroke causes neuronal oxygen/energy deprivation, disrupting mitochondrial function including reduced membrane potential and bioenergetics, exacerbating neuronal injury. Mitochondrial defects are, therefore, a central neuropathological node and potential therapeutic target.
Ning Bian, Jianing Shen, Linwei Tian, Jinghui Li, Lu Yang, Bo Yuan, Shulin Li, Yuyu Niu, Lu Zhao, Jingkuan Wei   +9 more
wiley   +1 more source

E-cigarette liquids alter the biogenesis and properties of <i>Aggregatibacter actinomycetemcomitans</i> outer membrane vesicles. [PDF]

Front Cell Infect Microbiol
Khodabakhsh Majd M, Wu LY, Cuadra GA, Brown AC.   +3 more
europepmc   +1 more source

Angiopep-2-decorated bacterial outer membrane vesicles penetrate the blood-brain barrier for glioblastoma chemo-immunotherapy. [PDF]

Drug Deliv
Shah PT, Lou Z, Zhu X, Jin W, Chen C, Hu T, Guo P, Zhao X, Li F, Xiaoliang Y, Wu Z, Wu C.   +11 more
europepmc   +1 more source