Results 201 to 210 of about 188,394 (267)

Outlier Detection in Functional Data Using Adjusted Outlyingness. [PDF]

Entropy (Basel)
Feng Z, Hong X, Li Y, Song X, Zhang K.
europepmc   +1 more source

Interpretable Machine Learning Framework for Nb─Si Based Alloy Design with Enhanced Fracture Toughness

Advanced Science, EarlyView.
An interpretable machine learning framework integrating SHAP and PDP analysis identifies critical design descriptors from 139 physicochemical features for Nb─Si alloys. The framework achieves <7% prediction error and guides the discovery of Nb38.5Ti38.5Si3Zr18V2 alloy with 22.791 MPa·m1/2 fracture toughness, breaking the 20 MPa·m1/2 barrier.
Dezhi Chen, Chao Xu, Jingyue Yu, Qi Wang, Hongze Fang, Shuo Yin, Turab Lookman, Ruirun Chen   +7 more
wiley   +1 more source

Evaluating support for the debrief process for paediatric oncology trainee doctors and newly appointed consultants after child death. [PDF]

BMJ Paediatr Open
Senanayake U, Aubugeau-Williams P, Barnard G.   +2 more
europepmc   +1 more source

Single‐Cell Annotation and Localization via Integrating Spatial Transcriptomics Maps the Mouse Ocular Atlas and RAO Dynamics

Advanced Science, EarlyView.
We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du, Yinming Li, Ziyue Li, Yuedan Wang, Shaopeng Li, Yijie Wang, Yingying Qu, Bingyang Lv, Ying Li, Ting Chen, Yu Zhou, Xuan Xiao   +11 more
wiley   +1 more source

Causal Relationship Between 38 Dietary Factors, Including Sugar and Alcohol Intakes, and Polycystic Ovary Syndrome: A Two-Sample Mendelian Randomization Study. [PDF]

Int J Womens Health
Xu L, Zhang S, Shi W, Zou S.
europepmc   +1 more source

Imaging‐Guided Live Single‐Cell Lipid Profiling of Leader and Follower Cells During Collective Migration of Triple‐Negative Breast Cancer Cells

Advanced Science, EarlyView.
Integrated single‐cell mass spectrometry reveals distinct lipidomic signatures that differentiate leader and follower phenotypes in migratory breast cancer cells. Phenotype‐specific alterations across various lipid classes, including fatty acids and phosphatidylcholines, underpin functional heterogeneity.
Xiaoyue Huang, Judit González Riera, Mai Nguyen, Jeremy Broekhuis, Sylvia E. Le Dévédec, Ahmed Ali, Thomas Hankemeier   +6 more
wiley   +1 more source

A multidisciplinary RNA-guided approach to complement genomic analysis of unsolved patients with an inborn error of immunity. [PDF]

Front Immunol
Maassen WTK, Pape LCET, Niemeijer T, Heijink AM, Meems-Veldhuis MT, Boerrigter DJ, van der Vries G, Westers H, Johansson LF, van der Velde KJ, Swertz MA, Franke L, Legger GE, Lambeck AJA, Rutgers A, Jonkers IH, van Gijn ME, Zonneveld-Huijssoon E.   +17 more
europepmc   +1 more source

Engineered Optogenetic Circuits In Yeast with Self‐Sustained Outputs

Advanced Science, EarlyView.
Optogenetic quorum‐sensing (OptoQS) circuit enables Saccharomyces cerevisiae to record transient light stimulus with self‐sustained outputs. Panel a indicates the design of the OptoQS circuit based on G‐protein coupled receptor (GPCR) signaling cascade. Panel b indicates the mode of action of surrogate messenger‐mediated signal transmission at the cell
Cong Fan, Haofeng Chen, Yan Wang, Junyi Wang, Yueyang Chen, Yang Zhang, Jinting Guan, Jifeng Yuan   +7 more
wiley   +1 more source

Comparing Methods for Attributing Hospital Quality Metrics to Individual Physicians: Impact on Performance Assessment and Outlier Identification. [PDF]

J Gen Intern Med
Carmichael HL, Woller SC, Brown SM, Asch SM, Srivastava R, Pirozzi M, Peltan ID.   +6 more
europepmc   +1 more source

The population structure in the Baltic herring reflects natural selection and local adaptation. [PDF]

Proc Natl Acad Sci U S A
Goodall J, Pettersson ME, Andersson A, Dahlin I, Ryman N, Ståhl G, Wennerström L, Andersson L, Laikre L.   +8 more
europepmc   +1 more source