Results 231 to 240 of about 23,619,888 (317)

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

An Indoor UAV Localization Framework with ESKF Tightly-Coupled Fusion and Multi-Epoch UWB Outlier Rejection. [PDF]

Sensors (Basel)
Zhao J, Deng Z, Hu E, Su W, Lou B, Liu Y.   +5 more
europepmc   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

The role of placental DNA methylation in the pathogenesis of chronic intervillositis of unknown etiology. [PDF]

Clin Epigenetics
Inkster AM, Peñaherrera MS, Robinson WP, Terry J.   +3 more
europepmc   +1 more source

Enhanced Isotopic Ratio Outlier Analysis (IROA) Peak Detection and Identification with Ultra-High Resolution GC-Orbitrap/MS: Potential Application for Investigation of Model Organism Metabolomes. [PDF]

Metabolites, 2018
Qiu Y, Moir RD, Willis IM, Seethapathy S, Biniakewitz RC, Kurland IJ.   +5 more
europepmc   +1 more source

Data‐Driven Printability Modeling of Hydrogels for Precise Direct Ink Writing Based on Rheological Properties

Advanced Science, EarlyView.
A predictive model for 3D printability is developed by integrating rheological analysis, including the Large Amplitude Oscillatory Shear (LAOS) test, with machine learning. With prediction errors under 10%, the model shows that post‐extrusion recovery controls horizontal printability, while high‐strain‐rate nozzle flow dictates vertical printability ...
Eun Hui Jeong, Jiho Choi, Han Bi Park, Ji Woo Lee, Seo Yeon Bae, Byoung Soo Kim, ChangKyu Yoon, Jun Dong Park   +7 more
wiley   +1 more source

MUSICiAn: genome-wide identification of genes involved in DNA repair via control-free mutational spectra analysis. [PDF]

NAR Genom Bioinform
Seale C, Barazas M, van Schendel R, Tijsterman M, Gonçalves JP.   +4 more
europepmc   +1 more source

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

Grizzly bear population genomics across a coastal-interior ecotone in British Columbia, Canada. [PDF]

G3 (Bethesda)
Henson LH, Christensen KA, Sutherland BJG, Johnson HA, vonHoldt B, Stronen AV, Paquet PC, Moody J, Koop BF, Darimont CT.   +9 more
europepmc   +1 more source

Study on Outlier Detection Method in Survival Analysis: Weibull Regression Outlier Model

Journal of Biometrics & Biostatistics, 2018
Chang Shu, Tingting Qin, Xiaoping Chen, Ping Yin   +3 more
openaire   +1 more source