Results 191 to 200 of about 148,298 (266)

UGT1A1 genotype testing for irinotecan: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, EarlyView.
Abstract Irinotecan, a topoisomerase I inhibitor, is available as both non‐pegylated and pegylated formulations. The non‐pegylated formulation is licensed for use in advanced colorectal cancer either in combination with other agents or as monotherapy.
Dharmisha Chauhan, Cinzia Dello Russo, Jack Thompson, Dyfrig A. Hughes, Katherine Payne, Maria Tsakiroglou, Paul Ross, Rena Chauhan, Simon Jenkinson, Jessica Keen, Sophie Harding, Eleanor Lau, Michael Braun, Roshan Agarwal, Richard Adams, Elisabeth Rolf, Farah Al‐Sheikhli, Sarah Mitchell, Ruth Hammond, Rosie Roberts, Lorna Cairns, Shirley Heggarty, Janet Graham, Justin Mencel, Munir Pirmohamed   +24 more
wiley   +1 more source

Early-Phase Oral Antiviral Use and Post-COVID-19 Condition in Outpatients.

JAMA Netw Open
Hibino M, Shintani A, Murayama H, Morikawa N, Maeda K, Nishiguchi S, Monma E, Harada H, Takagi T, Kuroyanagi S, Endo K, Terada Y, Kinoshita M, Yoden T, Miyazawa S, Higashiue S.   +15 more
europepmc   +1 more source

Cardiovascular and neuropsychiatric outcomes with PCSK9 inhibitors in atherosclerotic cardiovascular disease: A retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Study design and main findings. After 1:1 propensity score matching, 60 885 PCSK9 inhibitor users and 60 885 statin‐only users with ASCVD were compared. Kaplan–Meier curves show 12‐month cumulative event‐free survival for MACE, psychiatric disease, and neurodegenerative disease.
Tianshu Gu, Yang Chen, Nan Zhang, Uazman Alam, Riccardo Proietti, Tong Liu, Kang‐Yin Chen, Gregory Y. H. Lip   +7 more
wiley   +1 more source

Prevalence of suicidal thoughts and behaviors among individuals with mental disorders in Africa: a systematic review and meta-analysis of the past 25 years. [PDF]

BMC Psychiatry
Ghizlane C, Zougrar I, Benayad A, Abdelaal O, Bouaddi O, Elbadisy I, Bitanihirwe B, Boutayeb S, Belyamani L, Husky M, Khalis M.   +10 more
europepmc   +1 more source

Clozapine:norclozapine ratio as a marker of metabolic risk and therapeutic response and effect of valproate on clozapine levels

British Journal of Clinical Pharmacology, EarlyView.
Aims Clozapine is the most effective antipsychotic in treatment‐resistant schizophrenia. Clozapine causes weight gain and increased diabetes risk. The role of its metabolite norclozapine and clozapine:norclozapine ratio (CLZ/NCLZ) in metabolic effects has been debated.
Susanna Maria Rask, Miina Lamminmäki, Olli Kampman, Mari Hämäläinen, Eeva Moilanen, Niko Seppälä, Anssi Solismaa   +6 more
wiley   +1 more source

Direct and indirect associations of hypochondriasis with suicidality in psychiatric outpatients: mediating roles of anxiety and depression. [PDF]

Front Psychiatry
Lim J, Kim H, Yang C, Moon H, Kim Y, Ahn J, Jang J, Kim SJ.   +7 more
europepmc   +1 more source

Discrepancies between patients' and gastroenterologists' perceptions of diagnosis and treatment in ulcerative colitis: a multicenter retrospective study. [PDF]

Ther Adv Gastroenterol
Fan Z, Li R, Liu X, Cao Q, Zhu W, Chen M, Fan Y, Hu N, Wang Y, Lv X, Ye M, Zhu L, Yang X, Guo H, Xiao F, Chen N, Zhang H, Chen Y, Wu K, Liang J.   +19 more
europepmc   +1 more source

Health-related quality of life and six-month hospitalization in older outpatients with heart failure with reduced ejection fraction: a prospective observational study. [PDF]

Health Qual Life Outcomes
Nguyen HT, Nguyen HTM, Nguyen HQ.
europepmc   +1 more source

Prevalence and Distribution of Axis Subtypes of Refractive Astigmatism in Mexican Outpatients: A Nationwide Multicenter Clinic-Based Cross-Sectional Study. [PDF]

J Clin Med
Magaña-Lizárraga JA, García-Gil A, Contreras-Espinoza RD, Espinoza-Angulo E, Machado-Jiménez H, Luna-Ruiz-Esparza MA, Gómez-Campaña H, Campos-Romero A, Alcántar-Fernández J.   +8 more
europepmc   +1 more source