Results 111 to 120 of about 58,192 (306)

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, EarlyView.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

The diagnostic accuracy of two human epididymis protein 4 (HE4) testing systems in combination with CA125 in the differential diagnosis of ovarian masses [PDF]

, 2011
Background: Cancer antigen 125 (CA125) is the best known single tumor marker for ovarian cancer (OC). We investigated whether the additional information of the human epididymis protein 4 (HE4) improves diagnostic accuracy.
Burges, Alexander, Fuerst, Sophie, Hertlein, Linda, Hofmann, Karin, Kirschenhofer, Angela, Krocker, Katja, Lenhard, Miriam, Mayr, Doris, Nagel, Dorothea, Stieber, Petra   +9 more
core   +1 more source

Expanding the Phenotype of TUFM‐Related Combined Oxidative Phosphorylation Deficiency 4

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Combined oxidative phosphorylation deficiency 4 (COXPD4) is a rare mitochondrial condition caused by biallelic deleterious variants in the nuclear‐encoded gene TUFM. To date, most individuals with COXPD4 have presented with encephalopathy, hypotonia, and abnormal brain imaging. Many of the reported individuals died in infancy. We aim to expand
Noémie Villeneuve‐Cloutier, Jodi Warman‐Chardon, Danielle K. Bourque   +2 more
wiley   +1 more source

Hydatid Cyst of Ovary: A Case Report [PDF]

Iranian Journal of Medical Sciences, 2009
Echinococcus granulosus is considered the major cause of humanhydatid cysts. Usually the duration of cyst formation is 10-20 years. This period shortens significantly upon rupture of aprimary cyst.
Mohsen Khosravi Maharlooei, Armin Attar, Amita Goran, Seddigheh Amuee, Arman Dehghan, AhmadMonabati   +5 more
doaj  

Ovarian hyperstimulation syndrome following surgical removal of a complete hydatidiform mole: a case report

Journal of Medical Case Reports, 2019
Background Generally, ovarian hyperstimulation syndrome develops after superovulation caused by ovulation-inducing drugs in infertile patients. However, ovarian hyperstimulation syndrome associated with natural pregnancy is rare, and most cases of ...
Hiroaki Tsubokura, Yohei Ikoma, Takuya Yokoe, Tomoo Yoshimura, Katsuhiko Yasuda   +4 more
doaj   +1 more source

Ileal Endometriosis [PDF]

, 2009
Endometriosis at the ileum site is a rare case and among the difficult cases of endometriosis. Intestinal endometriosis may cause obstructing symptoms, which is difficult to be distinguished from Malignant or inflammatory disease.
Handjari, D. R. (Diah), Simadibrata, M. (Marcellus), Tedjasaputra, T. R. (Tjahjadi)   +2 more
core   +1 more source

Streamlining Diagnosis of Bardet–Biedl Syndrome: New Diagnostic Algorithm With Updated Criteria

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Considerable advances have been made in our understanding of Bardet–Biedl syndrome (BBS), particularly in its core clinical features and molecular genetics, warranting an update to the existing diagnostic criteria framework. Using a rigorous, evidence‐based, and consensus‐driven process, a multidisciplinary group of international experts and ...
Jeremy J. Pomeroy, Jesse Richards, Brooke R. Sweeney, Seema Kumar, Katie E. Queen, Joshua Zaritsky, Carl H. Cramer, Elias I. Traboulsi, Brittni A. Scruggs, Erica E. Davis, Ekaterina Keifer, Emma McGibbon, Timothy Ogden, Bendert De Graaf, Tonia Hymers, Elizabeth Forsythe, Philip Beales   +16 more
wiley   +1 more source

Remote rupture of ovarian dermoid cyst: A curious case report

Radiology Case Reports
Ovarian dermoid cysts are usually asymptomatic and detected incidentally. However, they can have variable presentation especially when they are associated with complications.
Abhikanta Khatiwada, MD, Anamika Jha, MD, Kundan Marasini, MD, Aalok Kumar Yadav, MD, Rajiv Paudel, MS, Sharada KC, MD   +5 more
doaj   +1 more source

Management of adnexal torsion [PDF]

, 2014
Objective: To evaluate clinical findings, operative reports, the pathological results of patients with diagnosis of adnexal torsion. Methods: Fourteen patients with diagnosis of adnexal torsion who presented to our clinic between January 2009 and March ...
Bekir Sıtkı İsenlik, Birsen Sahillioğlu, Mete Çağlar, Neslihan Erkal, Selahattin Kumru   +4 more
core   +1 more source

A novel mouse model of endometriosis: Simulating the recurrent hemorrhagic microenvironment of clinical lesions

Animal Models and Experimental Medicine, EarlyView.
To address the limitations of existing models, this study innovatively established a mouse model of endometriosis (EMs) capable of mimicking cyclic bleeding. Our results confirmed that this model recapitulates the complete pathological progression from ectopic lesion establishment to systemic responses, exhibiting superior clinical relevance compared ...
Yu Zhuang, Yan Zan, Tiantian Ma, Xiaoquan Huang, Junwei Li, Liangjun Xia, Yuping Sa, Youbing Xia   +7 more
wiley   +1 more source