Results 121 to 130 of about 1,085,590 (343)

Exosomes promote pre-metastatic niche formation in ovarian cancer. [PDF]

, 2019
Ovarian cancer is one of the most common gynecological malignancies. Upon initial diagnosis, the majority of patients present with widespread metastatic growth within the peritoneal cavity. This metastatic growth occurs in stages, with the formation of a
Dean, Dylan C, Duan, Zhenfeng, Feng, Wenlong, Hornicek, Francis J, Shi, Huirong   +4 more
core   +2 more sources

T Cell‐Independent Role of PD‐L1 in Kidney Repair: Mitigation of Tubular DNA Damage via PD‐L1/BRCA1 Interaction Following AKI

Advanced Science, EarlyView.
PD‐L1 is primarily expressed in renal tubules and upregulated in both murine models of AKI and renal biopsy samples from patients with AKI. PD‐L1 can promote adaptive TECs repair through interacting with BRCA1, independent of its canonical immunomodulatory function of T cells, and PD‐L1 supplementation may represent a promising therapeutic strategy for
Wei Jiang, Tao‐Tao Tang, Wei‐Jie Ni, Jin‐Xuan Wei, Liang‐Yun‐Zi Jiang, Qing Yin, Yi‐Lin Zhang, Zuo‐Lin Li, Yi Wen, Xin‐Lu Wang, Jun‐Yuan Shen, Xiao‐Jun Ouyang, Ming‐Zhu Zheng, Jian Xu, Xiaofei An, Lin‐Li Lv, Bi‐Cheng Liu, Bin Wang   +17 more
wiley   +1 more source

Efficacy of Sclerotherapic Agents in the Treatment of Simple Ovarian Cysts Created by Experimental Rat Model

İstanbul Medical Journal, 2020
Introduction:The purpose of this study is to investigate the effects of tetracycline (TC), clarithromycin (CM) and bleomycin (BLM) on the cyst diameter and ovarian tissues in the treatment of simple ovarian cysts.Methods:We employed Wistar albino female ...
Ünal Bakal, Mehmet Saraç, Tugay Tartar, Remzi Atılgan, Tuncay Kuloğlu, Adile Ferda Dağlı, Ahmet Kazez   +6 more
doaj   +1 more source

Low-Dose Oral Sirolimus and the Risk of Menstrual-Cycle Disturbances and Ovarian Cysts: Analysis of the Randomized Controlled SUISSE ADPKD Trial

PLoS ONE, 2012
Sirolimus has been approved for clinical use in non proliferative and proliferative disorders. It inhibits the mammalian target of rapamycin (mTOR) signaling pathway which is also known to regulate ovarian morphology and function.
Matthias Braun, James Young, C. Reiner, Diane Poster, F. Krauer, A. Kistler, P. Kristanto, Xueqi Wang, Yang Liu, J. Loffing, G. Andreisek, A. von Eckardstein, O. Senn, R. Wüthrich, A. Serra   +14 more
semanticscholar   +1 more source

Balancing Stealth and Targetability: cCPP‐ and PEG‐Modified Liposomes for the Targeted Delivery of Anti‐HER2 Nanobodies

Advanced Science, EarlyView.
This study addresses the rapid renal clearance of anti‐HER2 nanobodies by developing specialized liposomal carriers. It details the formulation of dual modified liposomes, demonstrating how PEGylation preserves structural integrity and cell‐penetrating peptides enhance cellular interaction.
Giulia Pander, Maria del Pilar Palacios Cisneros, Clara Certa, Megan Stierli, Katharina Beck, Nicolas Färber, Lisa Blank, Fiona Tanner, Eric Mühlberg, Sabrina Wohlfart, Christian Kleist, Jörg Huwyler, Gert Fricker, Walter Mier, Philipp Uhl   +14 more
wiley   +1 more source

Improved early detection of ovarian cancer using longitudinal multimarker models [PDF]

, 2019
© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the ...
Blyuss, Oleg, Gentry-Maharaj, Aleksandra, Gunu, Richard, Jacobs, Ian, Kalsi, Jatinderpal, Menon, Usha, Ryan, Andy, Timms, John F., Whitwell, Harry J., Worthington, Jenny, Zaikin, Alexey   +10 more
core   +3 more sources

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, EarlyView.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Septated ovarian cyst and its management through Ayurvedic approaches: An experience in a single case

Journal of Ayurveda Case Reports
Ovarian cysts are fluid-filled sacs that form in ovaries and are very common nowadays. Ovarian cysts sometimes feature internal partitions, known as septa, which divide them into multiple compartments.
Nidhi Tahlan, Meenakshi Pandey
doaj   +1 more source

The Diagnostic Accuracy of Abdominal Ultrasound Imaging for Detection of Ovarian Masses [PDF]

Background/Objective: Detection of the tissue diagnosis of ovarian space occupying lesions (OSOL) has remained a challenging task for sonographers since many adnexal masses have nonspecific sonographic appearances.
رفاهی, سهیلا, مغانگرد, فروغ, پورعیسی, مسعود   +2 more
core  

Expanding the Phenotype of TUFM‐Related Combined Oxidative Phosphorylation Deficiency 4

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Combined oxidative phosphorylation deficiency 4 (COXPD4) is a rare mitochondrial condition caused by biallelic deleterious variants in the nuclear‐encoded gene TUFM. To date, most individuals with COXPD4 have presented with encephalopathy, hypotonia, and abnormal brain imaging. Many of the reported individuals died in infancy. We aim to expand
Noémie Villeneuve‐Cloutier, Jodi Warman‐Chardon, Danielle K. Bourque   +2 more
wiley   +1 more source