Results 241 to 250 of about 257,086 (309)

Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors

Advanced Science, EarlyView.
This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng, Peipei Wang, Pengfei Wang, Jiamin Wang, Baiyang Li, Daqing Fang, Jian He, Xiaobei Hu, Weijuan Kan, Yubo Zhou, Chunpu Li, Jia Li, Hong Liu   +12 more
wiley   +1 more source

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source

T Cell‐Independent Role of PD‐L1 in Kidney Repair: Mitigation of Tubular DNA Damage via PD‐L1/BRCA1 Interaction Following AKI

Advanced Science, EarlyView.
PD‐L1 is primarily expressed in renal tubules and upregulated in both murine models of AKI and renal biopsy samples from patients with AKI. PD‐L1 can promote adaptive TECs repair through interacting with BRCA1, independent of its canonical immunomodulatory function of T cells, and PD‐L1 supplementation may represent a promising therapeutic strategy for
Wei Jiang, Tao‐Tao Tang, Wei‐Jie Ni, Jin‐Xuan Wei, Liang‐Yun‐Zi Jiang, Qing Yin, Yi‐Lin Zhang, Zuo‐Lin Li, Yi Wen, Xin‐Lu Wang, Jun‐Yuan Shen, Xiao‐Jun Ouyang, Ming‐Zhu Zheng, Jian Xu, Xiaofei An, Lin‐Li Lv, Bi‐Cheng Liu, Bin Wang   +17 more
wiley   +1 more source

Endometrial Dysfunction in Women with Ovarian and Uterine Tumors: What Is Known and What Should Be Learned? [PDF]

Int J Mol Sci
Mikhaleva LM, Orazov MR, Dolgov ED, Mikhalev SA, Gioeva ZV, Shakhpazyan NK, Pechnikova VV, Gushchin MY.   +7 more
europepmc   +1 more source

First reported case of triple benign ovarian collision tumor of the left ovary mimicking malignancy on ultrasound and CT imaging: sclerosing stromal tumor, serous cystadenoma, and fibroma. [PDF]

Oxf Med Case Reports
Alwaraa E, Salloum H, Ahmad M, Daoud A, Al-Janabi MAH.   +4 more
europepmc   +1 more source

Clinical and diagnostic aspects of ovarian neoplasm management

V.І. Pyrohova, Ірина Іванівна Охабська, S.О. Shurpyak   +2 more
openalex   +2 more sources

Benign mixed epithelial ovarian tumor with mucinous, serous, and transitional components: a rare case report. [PDF]

Oxf Med Case Reports
Ali BM, Hasan L, Daoud A, Hussein Al-Janabi MA.   +3 more
europepmc   +1 more source

A Rare Massive Seromucinous Cystadenoma of the Ovary in a 26-Year-Old Female Persisting for 9 Years: A Case Report. [PDF]

Case Rep Obstet Gynecol
Kakeh M, Alhalabi M, Wazan W, Abbassi R, Kanjawi A, Abbassi H.   +5 more
europepmc   +1 more source

Mucinous cystic neoplasm of the spleen with ovarian like stroma: a rare entity

Thulasiayya Sambamoorthy, Aravind Kumkod, Athulya Ajith, Akash Mysore Venkatesh, Mahesh Tiwari   +4 more
openalex   +2 more sources