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Antiosteoporotic activity of icariin in ovariectomized rats

Phytomedicine, 2009
Icariin was evaluated for its antiosteoporotic activity in an ovariectomized rat model of osteoporosis. The rats were divided into sham and OVX groups. The OVX rats were then subdivided into five groups treated with water, nylestriol (1 mg/kg body weight, weekly, orally) or icariin (ICA) (5, 25, and 125 mg/kg body weight, daily, orally) for 12 weeks ...
L.-L. Xu, Hua Nian, S.-S. Nian, M.-H. Ma
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Estrogen restores brain insulin sensitivity in ovariectomized non-obese rats, but not in ovariectomized obese rats

Metabolism, 2014
We previously demonstrated that obesity caused the reduction of peripheral and brain insulin sensitivity and that estrogen therapy improved these defects. However, the beneficial effect of estrogen on brain insulin sensitivity and oxidative stress in either ovariectomy alone or ovariectomy with obesity models has not been determined.
Nipon Chattipakorn   +2 more
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Effects of estradiol on corticosterone secretion in ovariectomized rats

Journal of Cellular Biochemistry, 1999
The effects of estradiol benzoate (EB) on steroidogenesis in rat zona fasciculata-reticularis (ZFR) cells were studied. Female rats were ovariectomized (Ovx) for 2 weeks and then injected subcutaneously with oil or EB for 3 days before decapitation.
Paulus S. Wang   +7 more
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Effects of dexamethasone, corticosterone, and ACTH on lordosis in ovariectomized and adrenalectomized-ovariectomized rats

Pharmacology Biochemistry and Behavior, 1980
The involvement of the pituitary-adrenocortical axis in the control of the lordosis reflex was investigated; In Experiment 1, estrogen-primed ovariectomized (ovx) and adrenalectomized-ovariectomized (adx-ovx) females were treated chronically with dexamethasone, a compound blocking ACTH release from the pituitary.
Boris B. Gorzalka, Denys de Catanzaro
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Estrogen modulation of NMDA-induced seizures in ovariectomized and non-ovariectomized rats

Brain Research, 2003
The objective of this study was to examine the neuroprotective effects of estrogen in response to N-methyl-D-aspartate (NMDA)-induced seizures in both male and female rats. Thirty-eight Long-Evans rats were divided into five groups: ovariectomized females, non-ovariectomized females, ovariectomized females with estrogen replacement (10 microg 17beta ...
Cynthia A. Standley   +1 more
openaire   +3 more sources

Effect of whole body vibration therapy on circulating serotonin levels in an ovariectomized rat model of osteoporosis

Iranian Journal of Basic Medical Sciences, 2014
Objective(s): Studies have reported that whole body vibration (WBV) played a vital role in bone remodeling. Circulating serotonin is also involved in negative regulating bone mass in rodents and humans.
Qiushi Wei   +7 more
semanticscholar   +1 more source

The Ovariectomized Mice and Rats

2011
The most common animals that are used for experimental studies are rodents, mainly rats and mice. Osteoporosis-related research is no exception. As early as 1985, ovariectomized (OVX) rats were used to study postmenopausal osteoporosis.
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Effects of genistein on hippocampal neurodegeneration of ovariectomized rats

Journal of Molecular Neuroscience, 2007
To investigate the mechanism underlying the neurodegeneration of postmenopausal women, the effect of genistein on hippocampal neurodegeneration was investigated in ovariectomized (OVX) Sprague-Dawley rats. Three-month-old female Sprague-Dawley rats were randomly divided into four groups: sham operated; OVX only; genistein-treated OVX (OVX-genistein ...
Jie Xu   +4 more
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The effect of clomiphene citrate on osteoporosis in ovariectomized rats

Archives of Gynecology and Obstetrics, 2008
The aim of this study was to investigate whether clomiphene citrate (CC) administration could be a new therapeutic agent in case of contraindication of estrogen therapy for hormone-dependent osteoporosis and to show the changes in bone structure by histomorphometric analysis in ovariectomized rats administered CC.This study was carried out in the ...
Uyar Y.   +4 more
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Effects of misoprostol on lipoprotein (a) levels of ovariectomized rats

Fertility and Sterility, 1999
To determine the effects of misoprostol on plasma lipoprotein (a) concentrations of ovariectomized rats.Controlled prospective study.Animal research laboratory.Four-month-old female Sprague-Dawley rats.Blood samples were obtained before and 60 days after ovariectomy, and the rats were divided into three groups.
Sonmez, AS   +5 more
openaire   +3 more sources

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