Results 71 to 80 of about 18,016,189 (287)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Over current protection relay using pic micro controller [PDF]

, 2007
Electrical Power System protection is required for protection of both user and the system equipment itself from fault,hence electrical power system is not allowed to operate without any protection devices installed.
Zoolnasri, Abu Harun
core   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Study on the Influence of Pulse Current Cathodic Protection Parameters of Oil Well Casing

Advances in Materials Science and Engineering, 2019
Pulse current cathodic protection had obvious advantages over traditional DC cathodic protection, but when square-wave pulse current was used for cathodic protection of oil well casing, the influence of pulse protection parameters on potential ...
Xiang-qian Xu, Hao-bin Zhou
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Power Control of a Nonpitchable PMSG-Based Marine Current Turbine at Overrated Current Speed With Flux-Weakening Strategy [PDF]

, 2014
This paper deals with power control strategies for a fixed-pitch direct drive marine current turbine (MCT) when the marine current velocity exceeds the rated value corresponding to the MCT nominal power.
SCUILLER, Franck, CHARPENTIER, Jean-Frederic, Zhou, Zibhin, BENBOUZID, Mohamed, ZHOU, Zhibin, TANG, Tianhao, Charpentier, Jean Fréderic   +6 more
core   +1 more source

Perancangan Rele Arus Lebih Dengan Karakteristik Invers Berbasis Mikrokontroler Atmega 8535

Jurnal Nasional Teknik Elektro, 2012
Untuk melindungi peralatan listrik dari kerusakan akibat gangguan hubung singkat atau short circuit  penyebab masalah yang harus diaman diperlukan suatu alat pengaman arus lebih (over current protection atau over current relay (OCR)).
Cahayahati ., Mirza Zoni Zoni
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A New GPS-based Digital Protection System for Smart Grids in Loop Structure

EAI Endorsed Transactions on Energy Web, 2014
This paper presents a new digital protection system to solve the protection challenges in future smart grids, i.e., fast protection and fault isolation in a loop-structured system with limited magnitude of fault current.
X. Liu, M. Steurer, M. Yu
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source