Results 91 to 100 of about 1,033,556 (314)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Design, construction and simulation of a circuit breaker-based feeder pillar with over current and earth-fault protection cum digitalized voltmeter

open access: yes, 2014
This research embodies the design, construction and simulation of a feeder pillar (415VAC) with over-current, overload and earth-fault protection with the aid of a phase sequence relay, contactor, earth-leakage circuit breaker and three-phase overload ...
Azuatalam, D.T.   +4 more
core  

A New Gate Driver for IGBT Devices with Multi-protections

open access: yes机车电传动, 2015
The process of IGBT switching was analyzed, and then a new gate driver with multi-protections was designed. The contractive researches between new gate driver and common gate driver and researches on module short circuit were also done.
XIE Shunmeng   +5 more
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

FBG-based fibre-optic current sensors for power systems protection : laboratory evaluation

open access: yes, 2009
Conventional differential current unit protection schemes rely on a pair of electronic protection relays that measure current phasors separately at the boundaries of the protected zone.
Niewczas, Pawel   +3 more
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Real-time teleprotection testing using IP/MPLS over xDSL

open access: yes, 2013
Teleprotection for power systems is safety-critical and has demanding requirements for bandwidth, low latency, and low jitter. Traditionally, time-division multiplexing (TDM) using SONET/SDH circuits has been used to provide this quality of service ...
Blair, Steven Macpherson   +1 more
core  

Study on the Influence of Pulse Current Cathodic Protection Parameters of Oil Well Casing

open access: yesAdvances in Materials Science and Engineering, 2019
Pulse current cathodic protection had obvious advantages over traditional DC cathodic protection, but when square-wave pulse current was used for cathodic protection of oil well casing, the influence of pulse protection parameters on potential ...
Xiang-qian Xu, Hao-bin Zhou
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Perancangan Rele Arus Lebih Dengan Karakteristik Invers Berbasis Mikrokontroler Atmega 8535

open access: yesJurnal Nasional Teknik Elektro, 2012
Untuk melindungi peralatan listrik dari kerusakan akibat gangguan hubung singkat atau short circuit  penyebab masalah yang harus diaman diperlukan suatu alat pengaman arus lebih (over current protection atau over current relay (OCR)).
Cahayahati ., Mirza Zoni Zoni
doaj   +1 more source

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