Results 81 to 90 of about 15,088 (297)

DSG2+ Cancer Stem Cells Co‐Located With FAP+ Myofibroblasts in the Tumor Boundary That Determines the Efficacy of Immunotherapy in Non‐Small Cell Lung Cancer

open access: yesAdvanced Science, EarlyView.
Cancer stem cells (CSCs) in non‐small cell lung cancer display pronounced plasticity and spatial heterogeneity. By integrating single‐cell and spatial transcriptomics, this study defines a DSG2‐associated CSC program and reveals a tumor‐margin niche formed with FAP+ myofibroblasts.
Guangyu Fan   +8 more
wiley   +1 more source

Generational Perspective of Financial Literacy and Consumer Over-Indebtedness. Survey Evidence from Poland

open access: yesJournal of Banking and Financial Economics
Background and purpose of the article: The main aim of the article is to present financial literacy (FL) and consumer over-indebtedness (OI) according to the primary survey in Poland.
Beata Świecka
doaj   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

open access: yesAdvanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong   +5 more
wiley   +1 more source

ANALYSIS OF THE INFLUENCE OF A COMPANY’S INDEBTEDNESS ON THE FINANCIAL RISK [PDF]

open access: yesAnalele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2015
Awareness of indebtedness and financial risk represents a great importance not only for the management of the company but also for creditors, investors, institutional investors, rating agencies, etc.
LĂPĂDUȘI MIHAELA LOREDANA   +1 more
doaj  

The Regulation of Over-Indebtedness of Consumers in Europe [PDF]

open access: yesJournal of Consumer Policy, 2012
The economic crisis has fueled the debate on regulated state insolvencies. While debt relief is being considered for some states, citizens in some cases live their whole lives in debt. In some countries like Bulgaria, Italy, Croatia, Lithuania, and Poland, there are no consumer bankruptcy procedures which provide for an exemption from residual debt. In
openaire   +2 more sources

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

open access: yesAdvanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

From the Land of Homeowners to the Land of the Over-Indebted: Reciprocity, Solidarity and Projects of Systemic Transformation in Times of Crisis (Del país de los propietarios al país de los sobreendeudados: reciprocidad, solidaridad y proyectos ...)

open access: yesArs & Humanitas, 2014
During the recent housing bubble inSpain, becoming a home owner seemed to be the wisest strategy in order to access housing, and there was considerable social consensus about mortgage indebtedness as a necessary condition in order to attain this goal ...
Irene Sabaté
doaj   +1 more source

3D Bioprinted Fat‐Myocardium Model Unravels the Role of Adipocyte Hypertrophy in Atrial Dysfunction

open access: yesAdvanced Science, EarlyView.
A human‐derived 3D bioprinted fat–myocardium model is developed to investigate how adipocyte hypertrophy drives atrial dysfunction in obesity. Palmitate‐induced adipocyte hypertrophy promotes adipose dysfunction that impairs atrial cardiomyocyte metabolism and electrophysiology through both paracrine and direct interactions. This platform recapitulates
Lara Ece Celebi, Pinar Zorlutuna
wiley   +1 more source

Debt deflation processes in today’s institutional environment

open access: yesPSL Quarterly Review, 2015
In the observations of the economy as it moved towards the great collapse of the winter of 1932-33, the elements of what happens when the market system breaks down are revealed.
H.P. MINSKY
doaj   +1 more source

Financial literacy, financial behaviour and individuals' over-indebtedness [PDF]

open access: yes, 2013
This work analyses the impact of financial literacy and financial behaviour of individuals on the likelihood of over-indebtedness, controlling for socioeconomic factors, the type of mortgage and the event of a negative income shock. Using the data from the 2009 National Financial Capability Study of the United States, we consider three self-reported ...
Elisabete Santos, Margarida Abreu
openaire   +1 more source

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