Results 231 to 240 of about 504,949 (346)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Understanding and practices of over-the-counter drugs for self-care among students of different medical faculties in a low-and middle-income country. [PDF]

Ann Med Surg (Lond)
Khadka S, Kc R, Luitel A, Thapa Chhetri S, Gurung S, Panta PP, Waiba S.   +6 more
europepmc   +1 more source

Over the counter drugs: awareness and practice among the adults of Mushahar community

, 2020
Sanam Mahato, Shanti Bajracharya
openalex   +2 more sources

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

The Effects of Trade Names on the Misuse of Some Over-The-Counter Drugs and Assessment of Community Knowledge and Attitudes in Alkarak, Jordan. [PDF]

Patient Prefer Adherence
Shaqfeh MI, Alsayed AR, Hasoun LZ, Khader HA, Zihlif MA.   +4 more
europepmc   +1 more source

Risk of Serious Upper Gastrointestinal Toxicity With Over-the-Counter Nonaspirin Nonsteroidal Anti-inflammatory Drugs [PDF]

, 2005
James D. Lewis, Stephen E. Kimmel, A. Russell Localio, David C. Metz, John T. Farrar, Lisa Nessel, Colleen Brensinger, Karen McGibney, Brian L. Strom   +8 more
openalex   +1 more source

Reading Levels of Leaflets of Common Over-the-Counter Drugs in Ghana

, 2023
William Kodom Gyasi, Lawrence Kwadwo Owusu-Ansah, Marian Amponsaah Frimpong   +2 more
openalex   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Dataset of Raman spectroscopy responses for over-the-counter drugs in Paraguay, including acetylsalicylic acid, paracetamol, and ibuprofen. [PDF]

Data Brief
Rodas JRR, Ferreira F, Rivas-Martínez GI, Melquiades FL, Mello-Román JC, Costa AMDS, Amarilla S, Mendez F, Herrera EZ.   +8 more
europepmc   +1 more source