Results 71 to 80 of about 502,761 (307)

This Is Not a Myeloproliferative Neoplasm…

Pediatric Blood &Cancer, EarlyView.
Stephanie Juané Kennedy
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Perception of self-medication among university students in Saudi Arabia

Archives of Pharmacy Practice, 2014
The aim of this study is to assess self-medication practice among university students in the Al-Qassim Province of Saudi Arabia. A cross-sectional community-based survey was conducted by distributing a self-administered 18-item questionnaire among ...
Mustafa S Saeed, Ali S Alkhoshaiban, Yaser Mohammed Ali Al-Worafi, Chiau Ming Long   +3 more
doaj   +1 more source

Exploration of self-medication practice in Pokhara valley of Nepal

BMC Public Health, 2020
Background Self-medication (SM) is the practice of consuming medication without the consultation of physician. The drugs most commonly self-medicated are paracetamol, analgesics, ranitidine, oral rehydration solution and antibiotics. The objective of the
Sabita Paudel, Bijay Aryal
doaj   +1 more source

Using Sociology to End Chemical Dependency [PDF]

, 1992
Drawing on participant observations and interventions while counseling 160 heroin addicts over a two-year period, the author explores the possibilities and limitations of using sociology to counter his clients\u27 addictions to heroin and other drugs ...
Gurdin, J. Barry
core   +1 more source

Determinants of new drugs prescription in the Swiss healthcare market. [PDF]

, 2018
Drug markets are very complex and, while many new drugs are registered each year, little is known about what drives the prescription of these new drugs.
Decollogny, A., Eggli, Y., Piaget-Rossel, R., Taffé, P.   +3 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potentially inappropriate medication in older participants of the Berlin Aging Study II (BASE-II) - Sex differences and associations with morbidity and medication use [PDF]

, 2019
INTRODUCTION: Multimorbidity in advanced age and the need for drug treatment may lead to polypharmacy, while pharmacokinetic and pharmacodynamic changes may increase the risk of adverse drug events (ADEs).
A Calderon-Larranaga, A Meyer, A Renom-Guiteras, B Pesch, By the American Geriatrics Society Beers Criteria Update Expert P, C Coupland, C. Walker, CE Leonard, CH Vinkers, D Gerstorf, D O'Mahony, DM Fick, DM Nathan, E Sonnerstam, E Tommelein, Elisabeth Steinhagen-Thiessen, FR Motter, GE Miller, Gianluigi Forloni, HG Endres, I Schubert, Ilja Demuth, Juliane Bolbrinker, K Hedna, K Heser, KU Saum, L Bertram, M Abu Sin, M Butler, M König, M König, M Molokhia, Maximilian König, ME Charlson, MH Beers, ML Laroche, MM Wolfe, MP Oktora, N Kachru, N Masnoon, O Abraham, O Reich, P Gallagher, P Gallo, P Martinot, PH Novaes, PJ McLeod, R Linder, Reinhold Kreutz, RT Chlebowski, RU Kristensen, S Holt, S Trelle, Sarah Toepfer, SK Nothelle, SM Wallerstedt, ST DeKosky, U Schwabe   +57 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source