Results 111 to 120 of about 10,510,029 (299)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Wind Tunnel Study of Plume Dispersion over Hypothetical Urban Areas

, 2017
Gaussian dispersion models have been well received in the industry for decades but its accuracy for urban setting is questionable because their dispersion coefficients were largely determined empirically based on open-terrain configurations. We report in
Mo, Z, Wu, Z, Liu, CH
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Classical and Bayesian estimation of discrete poisson Agu-Eghwerido distribution with applications

Alexandria Engineering Journal
This study presents a novel single-parameter counting model that merges the Poisson distribution with the Agu-Eghwerido distribution. The newly developed model is referred to as the ''Poisson Agu-Eghwerido Distribution.'' We investigate major ...
Osama Abdulaziz Alamri
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

A one-parameter poisson–emrem model for count data: Theory and applications to cytogenetic and COVID-19 studies

Scientific Reports
This paper proposes the Poisson–Emrem (PEm) distribution, a new one-parameter discrete probability model obtained by compounding the Poisson and Emrem distributions.
Tabassum Naz Sindhu, Anum Shafiq, Hany Mohamed Hamouda, Tahani A. Abushal, Yasser M. Ayid   +4 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

A compound Poisson-Sujit framework for over-dispersed radiation monitoring data

Journal of Radiation Research and Applied Sciences
This paper proposes a novel one-parameter discrete probability model, termed the Poisson–Sujit (PSJT) model, developed by compounding the classical Poisson distribution with the recently introduced Sujit (SJT) model.
Tabassum Naz Sindhu, Ehab M. Almetwally, Anum Shafiq, Zawar Hussain, Tahani A. Abushal, A. Aldukeel   +5 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

An Empirical Study of Price Dispersion in Homogenous Goods Markets [PDF]

This paper presents the results of an empirical study of price dispersion in homogeneous goods markets. Modern economic theory suggests that inevitable asymmetries of information in markets lead to an equilibrium in which price dispersion is present even
Thierry Warin, Daniel B. Leiter
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