Results 171 to 180 of about 504,949 (347)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

The senseless war : the sentencing drug offenses arms race [PDF]

open access: yes, 2014
There has been a considerable increase in the penalties for drug trafficking following the United Nations Single Convention on Narcotic Drugs 1961, over fifty years ago.
Bagaric, Mirko   +2 more
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Self-Medication: Awareness and Attitude Among Undergraduate Medical Students in A Tertiary Care Medical College, Dhule

open access: yesNational Journal of Community Medicine, 2015
Background: The practice of self-medication is becoming more common worldwide and currently plays a major role in self-care. The objectives of our study were to determine the perception and level of awareness regarding over the counter over the counter (
Sandip Bharat Patil
doaj  

Over the counter drugs and self-medication: A worldwide paranoia and a troublesome situation in India during the COVID-19 pandemic. [PDF]

open access: yesAnn Med Surg (Lond), 2022
Ray I   +9 more
europepmc   +1 more source

Understandings and social practices of medications for Zimbabwean households in New Zealand [PDF]

open access: yes, 2011
Medications are a central part of health care. How medications are understood and used by people in everyday life remains unclear. This study looks at understanding and social practices of medications in everyday life for Zimbabwean households in New ...
Groot, Shiloh Ann Maree   +3 more
core   +1 more source

Stroke Associated With Sympathomimetics Contained in Over-the-Counter Cough and Cold Drugs [PDF]

open access: bronze, 2003
Carlos Cantú   +4 more
openalex   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

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