Results 31 to 40 of about 87,203 (259)

Hiperatividade do detrusor: comparação entre oxibutinina, eletroestimulação funcional do assoalho pélvico e exercícios perineais. Estudo randomizado Detrusor overactivity: comparative study among oxybutynin, functional electrostimulation and pelvic floor training. A randomized clinical trial

Revista Brasileira de Ginecologia e Obstetrícia, 2007
OBJETIVO: avaliar e comparar os efeitos da oxibutinina, da eletroestimulação e dos exercícios perineais no tratamento da hiperatividade do detrusor. MÉTODOS: foram randomizadas mulheres com idade variando de 35 a 80 anos, predominantemente brancas.
Raquel Martins Arruda, Gabriela Olbrich de Sousa, Rodrigo de Aquino Castro, Marair Gracio Ferreira Sartori, Edmund Chada Baracat, Manoel João Batista Castello Girão   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Botulinum toxin-A for the treatment of overactive bladder: UK contributions [PDF]

, 2013
Background: Botulinum toxin-A (BoNT/A) is now established second-line management for refractory overactivebladder (OAB) and recognised in many incontinence guidelines and pathways.
Fowler, CJ, Panicker, J. N., Fowler, C. J., Dowson, C, Khan, MS, Seth, JH, Dasgupta, P, Dasgupta, P., Panicker, JN, Sahai, A, Dowson, C., Seth, J. H., Khan, M. S., Sahai, Arun   +13 more
core   +1 more source

Administration of BAY 41-2272 prevents bladder dysfunction in nitric-oxide deficient rats [PDF]

Einstein (São Paulo), 2010
Objective: to evaluate the protective effects of BAY 41-2272, asoluble guanylate cyclase activator, on changes in cystometricparameters in rats deficient in nitric oxide (NO). Methods: Ratswere divided into the following groups: (a) control; (b) DMSO; (c)
Carlos Arturo Levi D’Ancona, Fabíola Zakia Taufic Mónica, Ricardo Reges, David Cohen, Fabio Henrique da Silva, Gilberto De Nucci, Edson Antunes   +6 more
doaj  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Relationship between the severity of coronary artery disease and overactive bladder

, 2021
Background: Overactive bladder is a urological disease that can seriously impair a person’s quality of life, however its etiology remains unclear. The aim of this study was to evaluate the relationship between overactive bladder and SYNTAX score, which ...
Ceyhun, Gökhan, Erbay, Güven
core   +2 more sources

Multi-center, prospective, non-interventional, observational study on the efficacy and safety of Mirabek® in adult patients with overactive bladder [PDF]

Investigative and Clinical Urology
"Purpose: Mirabegron, the first-in-class beta-3 agonist, is the mainstay medication for overactive bladder (OAB). The aim of this study was to investigate the efficacy and safety of generic drugs of mirabegron (Mirabek®) in adults diagnosed with OAB ...
Jee Soo Park, Won Sik Jang, Jongchan Kim, Moon-Hwa Park, Won Sik Ham   +4 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

mapping in patients with overactive bladder

, 2022
Object Native T-1 mapping provides tissue-specific T-1 relaxation times, which can be used to identify structural changes in the various organs. The object of this article was to evaluate the bladder wall of patients with overactive bladder using native ...
Cankaya, Bahar, Gultekin, Mehmet Hamza, Mehmet Hamza Gultekin, Erdogan, Abdullah, Abdullah Erdogan, Yalcin, Ahmet, Bahar Yilmaz Cankaya, Ahmet Yalcin, YILMAZ ÇANKAYA, Bahar   +8 more
core   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source