Results 111 to 120 of about 400,796 (284)

Health‐related quality of life and patient‐reported outcome measures in economic evaluation of urological technologies: challenges and opportunities

BJU International, EarlyView.
Objective To examine the role of health‐related quality of life (HRQoL) assessments and patient‐reported outcome measures (PROMs) in the economic evaluation of urological interventions, highlighting methodological challenges, and identifying areas for future development.
Mohammed El Bahnasawi, Charlotte Moss, Netty Kinsella, Kathie Alexina Wong, Mieke Van Hemelrijck   +4 more
wiley   +1 more source

Dualsteric and dual‐acting modulation of muscarinic receptors by antagonist KH‐5

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Muscarinic acetylcholine receptors are key therapeutic targets, and ligands engaging both orthosteric and allosteric sites may offer improved selectivity and efficacy. Here, we investigated whether the muscarinic antagonist KH‐5 acts as a dualsteric antagonist and defined its mode of interaction with muscarinic receptors.
Alena Janoušková‐Randáková, Eva Dolejší, Nikolai Chetverikov, Jan Jakubík   +3 more
wiley   +1 more source

Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm

British Journal of Pharmacology, EarlyView.
Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley   +1 more source

Impact of mirabegron extended-release on the treatment of overactive bladder with urge urinary incontinence, urgency, and frequency

Research and Reports in Urology, 2013
Raymond T Lee,1 Mitchell Bamberger,2 Pamela Ellsworth31University of Massachusetts Medical School, 2UMass Memorial Medical Center, University of Massachusetts Medical School, Worcester, MA, 3Division of Urology/Surgery, Warren Alpert Medical School of ...
Lee RT, Bamberger M, Ellsworth P
doaj  

Comparison of the effects of transcranial direct current stimulation and transcutaneous tibial nerve stimulation on the urgency and frequency of women with overactive bladder syndrome: study protocol of a randomized clinical trial

Trials
Background Overactive bladder syndrome is common, with a prevalence of 12–17% among adults. Posterior tibial nerve stimulation is the primary nonpharmacological and conservative treatment for overactive bladder syndrome. While several human brain imaging
Zahra Gorji, MohammadReza Hadian Rasanani, Michael Nitsche, Tannaz Ahadi, Roya Khanmohammadi, Mona Gorji, Roxana Bazaz Behbahani, Vahid Rafiei Manesh   +7 more
doaj   +1 more source

Comparative effects of exercise-based pelvic floor training with kinesio-taping and electrical stimulation on overactive bladder symptoms in women

Здоров’я, спорт, реабілітація
Background and purpose This study aimed to assess the effectiveness of pelvic floor exercises combined with either Kinesio taping or electrical stimulation in reducing overactive bladder symptoms, enhancing ‘pelvic floor muscle strength, and ...
Aml Shatla, Soheir Elkosery, Efrem Kentiba, Ahmed Darwish   +3 more
doaj   +1 more source

Recreational Allergic Contact Dermatitis to “Epoxy UV” Resins: A New Source of Exposure to Hidden (Meth)acrylates

Contact Dermatitis, EarlyView.
We report three cases of allergic contact dermatitis (ACD) caused by acrylic resins used in creative hobbies, rather than by epoxy resins, despite these products being incorrectly labelled as “epoxy UV” resins. ABSTRACT Background Several cases of contact allergy to epoxy resins used in creative hobbies have been reported in recent years but not to ...
Nadia Raison‐Peyron, Sylvain Caillol, Jean Luc Bourrain, Eva Ibeka, Claire Negrell   +4 more
wiley   +1 more source

Long-term safety, efficacy, and tolerability of imidafenacin in the treatment of overactive bladder: a review of the Japanese literature

Patient Preference and Adherence, 2013
Naoya MasumoriDepartment of Urology, Sapporo Medical University School of Medicine, Sapporo, JapanAbstract: Imidafenacin is an antimuscarinic agent with high affinity for the M3 and M1 muscarinic receptor subtypes and low affinity for the M2 subtype, and
Masumori N
doaj  

Developmental stuttering with common and complex phenotypes

Developmental Medicine &Child Neurology, EarlyView.
Aim To describe the phenotypic spectrum associated with stuttering. Method Individuals with current or resolved developmental stuttering self‐referred. Surveys assessed stuttering characteristics (onset, negative impact, family history) and health (early development, other conditions). Speech and non‐verbal intelligence were assessed using conversation
Sarah E. Horton, Daisy A. Shepherd, Stephanie Siemers, Miya St John, Juliette Catherall, Ingrid E. Scheffer, Angela T. Morgan   +6 more
wiley   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source