Results 51 to 60 of about 175,097 (273)

Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2

Advanced Science, EarlyView.
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang, Chuanzan Zhou, Jiaoyan He, Pengpeng Huang, Rong Zhang, Huan Hu, Meng Jiao, Linyi Hu, Feng Liu, Xiaolong Qi, Xiang He, Yunkai Yang, Y Eugene Chinn, Dechao Feng, Dahong Zhang, Qi Zhang   +15 more
wiley   +1 more source

Our Knowledge of the Relationship of the Urinary Microbiome and Overactive Bladder: Past, Present, Future

, 2023
Purpose of Review This review covers the latest research on the urinary microbiome and its relationship to overactive bladder. We sought to understand what urinary microbiome characteristics may be associated with overactive bladder and what research has
Jacobsen, Gillian E., Amin, Katherine
core   +1 more source

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

A Bioinspired Underwater Soft Robot for Active Intravesical Liquid Delivery and Mixing

Advanced Intelligent Systems, EarlyView.
A bioinspired underwater soft robot is reported that integrates an elastic strain energy‐driven soft robotic pump with a programmable flexible magnetic valve, enabling remotely controlled, programmable, and sustained liquid release and mixing. This functionality is enabled by the synergistic integration of elastic strain energy‐driven pumping and ...
Jacob Katona, Sage Bernstein, Boyang Xiao, Amie Zhang, Ellen Lu, Evan Ticknor, Jeffrey J. Tosoian, Xiaoguang Dong   +7 more
wiley   +1 more source

Barriers to early and effective overactive bladder management in male patients with lower urinary tract symptoms.

PLoS ONE
Overactive bladder is underdiagnosed and undertreated in men as symptoms overlap with benign prostatic obstruction. This study identified barriers urologists encountered in effectively managing overactive bladder in men with lower urinary tract symptoms.
Paul Rasner, Maria Arcila-Ruiz, José Ailton Fernandes Silva, Umaphorn Nuanthaisong, Sung Yung Cho, Eric Chung   +5 more
doaj   +1 more source

Atherogenic Index of Plasma mediates the association between Life’s Crucial 9 with overactive bladder: a secondary data analysis from NHANES

Frontiers in Endocrinology
BackgroundSome studies suggest a potential link between cardiovascular health, lipid, and overactive bladder (OAB). Life’s Crucial 9 (LC9) is a recently developed method for assessing cardiovascular health, while the Atherogenic Index of Plasma (AIP ...
Hongyang Gong, Hongyang Gong, Xiaomei Lin, Shaoqun Huang   +3 more
doaj   +1 more source

Human urinary exosomes in bladder cancer patients : properties, concentrations and possible clinical application [PDF]

, 2015
OBJECTIVE: High grade bladder cancer is extremely aggressive. Early detection is thus an important challenge. De- velopment of non-invasive diagnostic tools particularly using urine samples could be of importance in the diagnosis and surveillance of ...
Mullen, Peter, Chapman, Alex, Hacker, Christian, Leung, Steve, Lucocq, John Milton, Bowness, James Simeon, McLornan, Liz, Cameron, Ruth, Harrison, David James, Powis, Simon John, Chinn, David John, Riches, Andrew Clive   +11 more
core   +1 more source

Initial Stay Time and Work‐Rest Scheduling During Consecutive Heavy‐Intensity Workdays in Hot Environments in Young and Older Males

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Introduction This study examined initial stay times (IST), defined as the duration of uninterrupted work before core temperature approaches recommended safety limits (38.0°C, ~1.0°C above baseline), and the efficacy of work‐rest cycles during repeated heavy work across consecutive workdays in young and older males.
Glen P. Kenny, Gil Bourgois, Sarah M. Taggart, Kelli E. McCormick, James J. McCormick, Leonidas G. Ioannou, Fergus K. O'Connor   +6 more
wiley   +1 more source

Overactive bladder in children

Canadian Urological Association Journal, 2017
Overactive bladder (OAB) is a highly prevalent disorder in the pediatric population. This condition is especially troublesome for pediatric patients and their families when associated with incontinence, since it negatively affects self-esteem and impairs children’s development.
Sophie, Ramsay, Stéphane, Bolduc
openaire   +3 more sources

ADNP‐Related Helsmoortel–Van der Aa Syndrome: A Review of the Literature and Clinical Recommendations for Assessment and Monitoring

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT ADNP‐related Helsmoortel–Van der Aa syndrome (ADNP‐related HVDAS) is a single gene form of autism spectrum disorder (ASD) caused by pathogenic sequence variants in the activity‐dependent neuroprotective protein (ADNP) gene. In addition to ASD, ADNP‐related HVDAS is associated with a wide range of cognitive, behavioral, and physical health ...
Jarrett Fastman, Ana Kolevzon, Paige Siper, Tess Levy, Jeffrey M. Saland, Yitzchak Frank, Robert Rapaport, Kayla Kupietzky, William E. Bennett Jr, Bruce Gelb, Sandra Bedrosian Sermone, Alexander Kolevzon   +11 more
wiley   +1 more source