Results 121 to 130 of about 16,705,258 (303)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Propeller Design Within the Overall Configuration of a Near-Space Airship

Drones
High-efficiency propeller design is essential for reducing the total mass of near-space airships under low-Reynolds-number conditions. This study optimizes the overall design parameters of near-space airships by integrating an efficient engineering ...
Guoquan Tao, Jizheng Zhang, Cong Xie, Ruixue Song, Bin Xiang, Jialin Chen, Qingyu Kang, Jun Yin   +7 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Overall assessment report : Ayitic goes global program

, 2019
The report provides a detailed analysis of skills training, student profiles, cultural and infrastructural barriers, and curriculum design. This two-year program enhanced participation among young Haitian women in the global digital economy. The goal was
3x3 Design
core   +1 more source

Design of shared steering control system with enhanced overall stability

Scientific Reports
The shared steering control (SSC) system is a solution for safe driving before achieving fully autonomous driving, however, its overall stability is easily affected by the driver characteristics.
Xueyun Li, Yiping Wang, Chuqi Su, Zhaoqing Wang, Xiaoyin Zheng, Jin Huang   +5 more
doaj   +1 more source

Overall Parameter Design and Transition Characteristics Analysis of Lift‑Tilt eVTOL

Nanjing Hangkong Hangtian Daxue Xuebao
The lift‑tilt configuration represents a prevalent architectural solution for electric vertical take‑off and landing （eVTOL） aircraft. Consequently， systematic investigations into its general parameter design principles， optimization methodologies， and ...
WANG Ziqi, XU Ming, SUN Donghong, ZHANG Wei, QIU Liangjun   +4 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

From measuring overall equipment effectiveness (OEE) to overall resource effectiveness (ORE).

, 2015
Purpose – Overall equipment effectiveness (OEE) provides a quantitative metric based on the elements availability, performance and quality for measuring the performance effectiveness of individual equipment or entire processes.
Garza-Reyes, Jose Arturo
core   +1 more source