Results 51 to 60 of about 7,675,902 (252)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

BIELOMATIC MACHINE PRODUCTIVITY ANALYSIS USING OVERALL EQUIPMENT EFFECTIVENESS (OEE) METHOD: CASE STUDY

open access: yesJournal of Industrial Engineering and Halal Industries, 2022
Productivity is an activity in producing an item or product using the most effective and efficient way possible. To increase the productivity of machines/equipment, it is necessary to apply TPM.
ari andriyas puji
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Weight and target value-based algorithm for predicting Overall Equipment Effectiveness

open access: yesActa Technica Jaurinensis
For industrial companies, accurate short and medium-term production planning is crucial for resource allocation and maximum utilization of manufacturing capacities.
Péter Dobra
doaj   +1 more source

Pengukuran Efektivitas Mesin Menggunakan Overall Equipment Effectiveness Untuk Dasar Usulan Perbaikan

open access: yesJurnal Ilmiah Teknik Industri, 2017
CV. Gracia has offset printing machines that often have downtime due to engine failures. The low effectiveness of the offset printing machines could cause losses to the company.
Bernandus Yoseph Bilianto   +1 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

APLIKASI OVERALL EQUIPMENT EFFECTIVENESS (OEE) DALAM UPAYA MENGATASI TINGGINYA DOWNTIME PADA STASIUN KETEL DI PG X JAWA TIMUR

open access: yesMultitek Indonesia, 2020
PG X in Jember is one of the agro-industries that processing sugar cane into sugar crystals. This factory works seasonally. To ensure the consumer demand for sugar, the sugar factory should operate efficiently during their production season.
Mahros Darsin
doaj   +1 more source

Overall equipment effectiveness for additive manufacturing [PDF]

open access: yes, 2019
Additive manufacturing is becoming a leading technology in the production of consumer parts. In order to compete with traditional methods which have had years to improve, additive systems must achieve a level of performance efficiency greater than it ...
Reid, Brian
core  

Analisa Overall Equipment Effectiveness pada Operasional Turbomachinery [PDF]

open access: yes, 2020
Salah satu peralatan penting dalam proses industi yang berperan penting pada proses transfer energi yaitu turbomachinery. Dalam suatu industri, nilai keandalan dan ketersediaan equipment sangat penting dalam mendukung kinerja suatu peralatan.
Permatasari, Inesya
core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

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