Results 101 to 110 of about 6,767,148 (304)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Nomogram application to predict overall and cancer-specific survival in osteosarcoma

, 2018
Weipeng Zheng,1,* Yuanping Huang,1,* Haoyi Chen,2 Ning Wang,1 Wende Xiao,3 YingJie Liang,3 Xin Jiang,1 Wenzhou Su,4 Shifeng Wen4 1Department of Orthopedics, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, Guangdong ...
Wang N, Huang Y, Liang Y, Jiang X, Xiao W, Wen S, Chen H, Zheng W, Su W   +8 more
core  

Overall survival.

, 2019
The overall survival rate at 5 years was 94.7%.
Takashi Nakano (253277), Hidemasa Kawamura (2620510), Takuya Kaminuma (6400784), Hiro Sato (545155), Nobuteru Kubo (2620519), Masahiro Onishi (6400790), Masahiko Okamoto (2298643), Nobuaki Ohtake (3193428), Tetsuo Sekihara (6400793), Yosuke Takakusagi (6400781), Tatsuji Mizukami (6400787)   +10 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Upregulation of the EMT marker vimentin is associated with poor clinical outcome in acute myeloid leukemia

Journal of Translational Medicine, 2018
Background Vimentin (VIM) is a type III intermediate filament that maintains cell integrity, and is involved in cell migration, motility and adhesion.
Sharon Wu, Yang Du, John Beckford, Houda Alachkar   +3 more
doaj   +1 more source

Is progression-free survival a more relevant endpoint than overall survival in first-line HR+/HER2− metastatic breast cancer?

, 2018
Anna Forsythe,1 David Chandiwana,2 Janina Barth,3 Marroon Thabane,4 Johan Baeck,5 Anastasiya Shor,1 Gabriel Tremblay6 1Health Technology Assessment Evidence, Purple Squirrel Economics, New York, NY, USA; 2Global Value and Access, Novartis Pharmaceutical ...
Thabane M, Forsythe A, Tremblay G, Shor A, Baeck J, Chandiwana D, Barth J   +6 more
core  

Ethnic inequalities in cancer survival in New Zealand: linkage study. [PDF]

, 2005
We explored the contribution of stage at diagnosis to ethnic disparities in cancer survival in New Zealand. We linked 115811 adult patients with invasive cancer registered on the cancer registry (1994 to 2002) to mortality data.
Tobias, Martin, Jeffreys, Mona, Ellison-Loschmann, Lis, Pearce, Neil, Stevanovic, Vladimir, Lewis, Chris, Blakely, Tony   +6 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Modest Improvement in Overall Survival for Patients With Metastatic Pancreatic Cancer [PDF]

, 2013
OBJECTIVES: Patients with pancreatic adenocarcinoma often present with distant metastatic disease. We aimed to assess whether improvements in survival of clinical trials translated to a population-based level.
Güller, Ulrich, Gloor, Beat, Pietrobon, Ricardo, Köberle, Dieter, Castleberry, Anthony W., Worni, Mathias, White, Rebekah R., Cerny, Thomas   +7 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source