Results 131 to 140 of about 1,877,507 (306)

Survival analysis after stereotactic ablative radiotherapy for early stage non-small cell lung cancer: a single-institution cohort study

Radiation Oncology
Background Stereotactic ablative radiotherapy (SABR) is the standard treatment for medically inoperable early-stage non-small cell lung cancer (ES-NSCLC), but which patients benefit from stereotactic radiotherapy is unclear.
Kamila Resova, Lukas Knybel, Tereza Parackova, Marian Rybar, Karel Cwiertka, Jakub Cvek   +5 more
doaj   +1 more source

Overall survival with abemaciclib in early breast cancer

Annals of Oncology
Adjuvant abemaciclib combined with endocrine therapy (ET) significantly improved invasive disease-free survival (IDFS) in patients with hormone receptor (HR)-positive, human epidermal growth factor 2 (HER2)-negative, node-positive, high-risk early breast cancer (EBC). The impact on overall survival (OS) remained unknown.In the phase III monarchE trial (
S. Johnston, M. Martin, J. O’Shaughnessy, R. Hegg, S.M. Tolaney, V. Guarneri, L. Del Mastro, M. Campone, J. Sohn, F. Boyle, J. Cortes, H.S. Rugo, M.P. Goetz, E.P. Hamilton, C.-S. Huang, E. Senkus, I. Cicin, L. Testa, P. Neven, J. Huober, Z. Shao, R. Wei, M. Munoz, B. San Antonio, A. Shahir, P. Rastogi, N. Harbeck   +26 more
openaire   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Preoperative hyperglycemia as an independent predictor of reduced long-term survival after gastric cancer surgery

European Journal of Medical Research
Objective While hyperglycemia is known to influence long-term outcomes in various malignancies, this study specifically investigates its association with overall survival after gastric cancer surgery.
Li Lv, Chunyu Chen, Hao Chen, Jintuan Huang, Wengcheong Tam, Yuhang Han, Bowei Zhang, Yi Liao, Zuli Yang   +8 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Probability of overall survival.

, 2018
Probability of overall survival.
Pierre Verrelle (559557), Toufic Khalil (5067074), Julian Biau (4285753), Michel Lapeyre (5067071), Jean-Jacques Lemaire (542430), Guillaume Dupic (5067077), Véronique Dedieu (5067080), Florian Magnier (5067083), Emmanuel Chautard (4285747), Juliette Moreau (2233273)   +9 more
core   +1 more source

Overall Survival [PDF]

, 2020
openaire   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Overall survival curve.

, 2015
Overall survival curve.
Jayesh P. Thawani (739898), Ashwin Ramayya (739897), Steven Brem (739902), Kalil G. Abdullah (739896), Lukasz Macyszyn (739899), Donald M. O’Rourke (739901), Maria Martinez-Lage (739900)   +6 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source