Results 201 to 210 of about 1,574,312 (309)

Final outcomes analysis of the cell product SQZ‐PBMC‐HPV Phase 1 trial in incurable HPV16+ solid tumors shows improved overall survival in patients with increased CD8+ T cell tumor infiltration [PDF]

Alice N. Weaver, Wade T. Iams, Jong Chul Park, Monica Mita, Udo Holtick, Michael S. Gordon, Kerry J. Rodabaugh, Neesha C. Dhani, Prakash Neupane, Matthew H. Taylor, Eric Duvall, Julia Jennings, Nathan R. Miselis, Scott Loughhead, Marshelle Warren, Howard Bernstein, Jens Peter Klußmann, Joaquina Baranda, Antonio Jimeno   +18 more
openalex   +1 more source

Pancreatic cancer drug improves overall survival [PDF]

Cancer, 2014
openaire   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Failure-to-rescue as a determinant of overall survival following resection for perihilar cholangiocarcinoma. [PDF]

JHEP Rep
Dong Y, Li Z, Podrascanin V, Eaton JE, Ilyas SI, Gores GJ, Warner SG, Nagorney DM, Smoot RL, Starlinger PP.   +9 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Photodynamic therapy for recurrent spinal diffuse midline glioma with a modest extension of overall survival: illustrative case. [PDF]

J Neurosurg Case Lessons
Fukumura M, Tani M, Kazuki R, Kashiwagi H, Kosaka T, Kawabata S, Nonoguchi N, Endo T, Takami T, Wanibuchi M.   +9 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Contemporary Nodal Management and Overall Survival of Older Patients with HR-/HER2+ Breast Cancer. [PDF]

Ann Surg Oncol
Cobb AN, Dong X, Makope A, Cohen L, Huang CC, Kong AL, Cortina CS.   +6 more
europepmc   +1 more source

Integrated nomograms to predict overall survival and recurrence-free survival in patients with combined hepatocellular cholangiocarcinoma (cHCC) after liver resection

, 2020
Tao Wang, Xianwei Yang, Huairong Tang, Junjie Kong, Shu Shen, Haizhou Qiu, Wentao Wang   +6 more
openalex   +2 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source