Results 181 to 190 of about 27,413 (305)

Investigation of deformation characteristics of gate and earth-rock dam systems under deep overburden conditions. [PDF]

Sci Rep
Liu B, Wang F, Zou D, Zhuo Y, Pang S.
europepmc   +1 more source

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

Mechanically Regulated Secretion: How Physical Forces Instruct the Secretory Pathway and Remodel the Secretome

Advanced Science, EarlyView.
Mechanical cues, including ECM stiffness, stretch, compression, shear stress, and traction forces, remodel trafficking across the secretory pathway, from the ER and Golgi to endolysosomal compartments and the plasma membrane. The resulting secretome reshapes ECM composition and tissue mechanics, establishing feedback loops that support homeostasis or ...
Domenico Russo, Seetharaman Parashuraman, Maria Luigia Maresca, Angela Francesca Dinoi, Alessia Calcagnì, Riccardo Rizzo   +5 more
wiley   +1 more source

Multi-method synergistic determination of the development height of the water-conducting fractured zone in the 82,209 working face. [PDF]

Sci Rep
Liu Z, Li H.
europepmc   +1 more source

Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation

Advanced Science, EarlyView.
Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir, Yagmur Ozendi, Gokhan Burcin Kubat, Keshav K. Singh   +3 more
wiley   +1 more source

Deformation characteristics of weakly cemented overburden in Western mining areas in China. [PDF]

Sci Rep
Zhang G, Zhang H, Li G, Chen J, Zhao L, Zhou G.   +5 more
europepmc   +1 more source

CW‐Pumped Amplified Spontaneous Emission From Thermally Evaporated CsPbBr3 Films

Advanced Science, EarlyView.
Thermally evaporated CsPbBr3 thin films sustain amplified spontaneous emission from short‐pulse toward quasi‐continuous‐wave excitation. Time‐resolved spectroscopy, controlled excitation, and substrate engineering reveal how excitation duration governs optical‐gain stability.
Yuliia Kominko, Willem Verheijen, Gabriele Rainò, Simon C. Boehme, Maksym V. Kovalenko, Sergii Yakunin   +5 more
wiley   +1 more source

Deep drilling on Mars: pneumatic chip clearing model for the RedWater mining system. [PDF]

Space Planet Resour
Stolov L, Palmowski J, Zacny K, Yen B, Mellerowicz B, Mank Z, Sanasarian L, Schultz J.   +7 more
europepmc   +1 more source

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

Analysis of the failure state of the Cenozoic clay layer in thin bedrock coal seam mining: A case study of Sanyuan coal mine. [PDF]

PLoS One
Wu G, Wang M, Wang L.
europepmc   +1 more source