Results 91 to 100 of about 43,209 (326)

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Discrete Element Analysis of Grouting Reinforcement and Slurry Diffusion in Overburden Strata

Applied Sciences
Research on the grouting reinforcement mechanism of overburden is constrained by the concealed and heterogeneous nature of geotechnical media, posing dual challenges in theoretical analysis and process visualization.
Pengfei Guo, Weiquan Zhao, Yahui Ma, Huiling Gen   +3 more
doaj   +1 more source

Inactivation of AXL in Cardiac Fibroblasts Alleviates Right Ventricular Remodeling in Pulmonary Hypertension

Advanced Science, EarlyView.
Pulmonary hypertension (PH) is a progressive condition with high morbidity and mortality, largely owing to right ventricular (RV) failure resulting from maladaptive remodeling. Our study provides strong evidence in support of a critical, detrimental role for AXL as a previously unrecognized determinant driving RV fibrotic pathology in PH.
Li‐Wei Wu, Min Chen, Chen‐Yu Jiang, Dai‐Ji Jiang, Xu Zhang, Xiao‐He Xu, Yi‐Wei Liu, Bei Feng, Lin‐Cai Ye, Yang‐Yang He, Xu Huang, Yi‐Chi Zhang, Xing‐Liang Zhou, Yi Shen, Tian‐Yu Liu, Li‐Jun Fu, Yi Yan, Hao Zhang   +17 more
wiley   +1 more source

Formation and evolution law of high-intensity mining ground fissures and damage reduction method

Meitan xuebao
High-intensity mining in the Shendong mining area has caused serious overburden and surface damage, which threatens the ecological security of the mining area.
Xiaobin LI, Quansheng LI, Fulian HE, Cun ZHANG, Penghua HAN, Yong ZHANG, Zhaopeng REN, Chuanjiu ZHANG, Yang WU   +8 more
doaj   +1 more source

Modelling an inverted belt filter [PDF]

, 1997
This project report describes the attempts to model the adhesive forces relevant to the manufacture of products such as fibre cement board. As they are made with an inverted belt filter, the mixture must adhere to the underside for a considerable time ...
Fowkes, N.D., Weber, R.O., White, L.R.
core  

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

Advanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen, Xinhui Zheng, Jieliu Li, Minyu He, Dongqi Fan, Xingyu Zhu, Qiming Zhai, Liangjing Xin, Tao Chen   +8 more
wiley   +1 more source

A Mussel‐Inspired Bioadhesive Patch to Selectively Kill Glioblastoma Cells

Advanced Science, EarlyView.
An innovative mussel‐inspired bioadhesive patch has been developed for post‐surgical glioblastoma treatment. The patch, which adheres strongly in biological environments, releases a localized treatment. This treatment, acting via reactive oxygen species, shows specific toxicity to glioblastoma cells.
Jose Bolaños‐Cardet, Sara Pugliese, Jordi Bruna, Daniel Ruiz‐Molina, Salvio Suárez‐García, Victor J. Yuste   +5 more
wiley   +1 more source

Promoting Autophagy Mitigates Stress‐Induced Remodeling in Patient iPSC‐CMs with the Phospholamban R9C Mutation

Advanced Science, EarlyView.
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu, Yawei Shen, Robert J. Barndt, Karim Sallam, Ying Tang, Cameron E. Brown, Xiao Li, Stephen Y. Chan, Joseph C. Wu, Qing Liu, Haodi Wu   +10 more
wiley   +1 more source

Study on the overburden failure features and microseismic measurements in non-pillar gob-side entry retaining by roof cutting

Gong-kuang zidonghua
In order to further study the failure law of overburden after the mining of non-pillar gob-side entry retaining by roof cutting technology, taking the S1201-II working face of Ningtiaota Coal Mine as the engineering background, physical similarity ...
ZHANG Yingyi, WANG Tong
doaj   +1 more source

Experimental Study on Sensitivity of Porosity to Pressure and Particle Size in Loose Coal Media

Energies, 2018
A new experimental method for characterizing the porosity of loose media subjected to overburden pressure is proposed based on the functional relationships between porosity, true density, and bulk density.
Chenghao Zhang, Nong Zhang, Dongjiang Pan, Deyu Qian, Yanpei An, Yuxin Yuan, Zhe Xiang, Yang Wang   +7 more
doaj   +1 more source