Results 121 to 130 of about 43,209 (326)

English for Study and Work: Coursebook in 4 books. Book 2 Obtaining and Processing Information for Specific Purposes [PDF]

, 2015
Подано всі види діяльності студентів з вивчення англійської мови, спрямовані на розвиток мовної поведінки, необхідної для ефективного спілкування в академічному та професійному середовищах.
Зуенок, И. И., Зуенок, Ирина Ивановна, Зуєнок, І. І., Зуєнок, Ірина Іванівна, Кострицкая, С. И., Кострицкая, Светлана Ивановна, Кострицька, С. І., Кострицька, Світлана Іванівна, Поперечна, Н. В., Поперечна, Неллі Василівна, Поперечная, Н. В., Поперечная, Нелли Васильевна, Швец, Е. Д., Швец, Елена Дмитриевна, Швець, О. Д., Швець, Олена Дмитрівна   +15 more
core  

CRISPLD2 Attenuates Intervertebral Disc Degeneration by Suppressing Oxidative Stress‐Induced Ferroptosis through the miR‐548I‐IL17A Axis

Advanced Science, EarlyView.
This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi, Fudong Li, Tianyi Zhao, Kaiqiang Sun, Danying Zhang, Chen Yan, Ximing Xu, Jingchuang Sun, Xulin Hu, Xin Yong, Jiangang Shi, Yuan Wang   +11 more
wiley   +1 more source

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

Advanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li, Xueqi He, Xinyuan Hao, Yu Zhang, Xin Zhao, Shuang Wang, Zhenru Wang, Haonan Du, Hongda Li, Lian Yi, Zhimin Du, Weijie Du   +11 more
wiley   +1 more source

Mechanical Overloading‐Induced Nanomineral Crystal Perturbation from the Osteochondral Interface: A Potential Initiator of Osteoarthritis

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang, Rong Ren, Zhan Su, Jiahao Zhou, Pinyin Cao, Sicheng Zhang, Zhen Li, Chao Li, Songsong Zhu   +8 more
wiley   +1 more source

Artificial Ground Freezing—On the Soil Deformations during Freeze–Thaw Cycles

Geotechnics
Artificial ground freezing (AGF) has emerged as a prominent treatment method due to its ability to mechanically strengthen the soil while reducing its permeability.
Zeina Joudieh, Olivier Cuisinier, Adel Abdallah, Farimah Masrouri   +3 more
doaj   +1 more source

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, EarlyView.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source

Stress‐Induced Melting Controlled Failure Mechanisms of Methane Hydrate

Advanced Science, EarlyView.
We study methane hydrate via nanoindentation and nuclear magnetic resonance (NMR), finding its regional melting and mechanical properties, challenging existing views on hydrogen‐bonded crystals. Abstract Methane hydrate, a kind of nonstoichiometric crystalline, attracted worldwide attentions as a promising substitute energy. Its Dissociation is thought
Yanlong Li, Yuan Zhou, Zhengcai Zhang, Minhui Qi, Yajuan Zhang, Yujing Jiang, Yunkai Ji, Qingguo Meng, Yongfu Sun, Nengyou Wu   +9 more
wiley   +1 more source

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Advanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu   +15 more
wiley   +1 more source

Movement behavior of rock strata in multi-level sublevel filling mining and forecasting of differential surface subsidence

Results in Engineering
To address issues such as ground pressure manifestation, rock beam fracture, and overburden displacement caused by multi-level sublevel filling mining of gently inclined medium-thick ore bodies, this study adopts the Fankou Lead-Zinc Mine as the ...
Fei Li, Yihui Feng, Haitao Ma, Yongming Yin, Xinai Lu, Chaoyu Zan   +5 more
doaj   +1 more source

An Enzyme‐Like Catalyzed Nanosheets for Redox Stress Oscillation Therapy Against Bacterial Infections

Advanced Science, EarlyView.
Bacterial biofilms form a physicochemical barrier. Their dense network structure and redox homeostasis confer high resistance to antimicrobial treatments and immune‐mediated killing and clearance. In this study, SnSe nanosheets with enzyme‐like properties and piezoelectric catalysis can oscillate to regulate bacterial redox homeostasis and improve the ...
Min Ge, Zhao Guo, Zhiming Zhang, Lanlu Lu, Zesong Ruan, Tingwang Shi, Yunfeng Chen, Ju Huang, Chaoliang Tan, Han Lin   +9 more
wiley   +1 more source