Results 141 to 150 of about 43,209 (326)

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

open access: yesAdvanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su   +18 more
wiley   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

open access: yesAdvanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo   +5 more
wiley   +1 more source

The Research of Water Immersion Test of loess under overburden pressure [PDF]

open access: gold, 2018
Yu Zhang   +5 more
openalex   +1 more source

A Universal Metal–Flavonoid Coating Strategy: Engineering Biomaterials for Diabetic Bone Regeneration

open access: yesAdvanced Science, EarlyView.
Construction of metal–flavonoid functionalized coatings on conventional bone repair materials. A one‐pot method is used to directly construct multifunctional metal–flavonoid coatings on the surface of traditional bone repair materials by selecting metal ions with osteogenic/angiogenic properties and flavonoids with reactive oxygen species scavenging ...
Chen Yang   +11 more
wiley   +1 more source

Designing Advanced Soft Magnetic Powder Cores with Ultralow Energy Loss by Combining Ultrasonic and Static Compaction

open access: yesAdvanced Science, EarlyView.
Increasing the density and homogeneity of soft magnetic composites are critical for achieving high power density and low core loss. This work proposes a novel strategy by combining ultrasonic‐assisted pressing and cold pressing. In this line, the density and permeability of magnetic core have been increased a lot, while the core loss is decreased ...
Xiaoying Huang   +15 more
wiley   +1 more source

A STUDY ON BEHAVIOR OF VU PIPE WITH OVERBURDEN PRESSURE UNDER APPLICATION OF INTERNAL LOADING METHOD

open access: diamond, 2021
Koki OYAMA   +4 more
openalex   +2 more sources

Tunable Plug‐and‐Play Meta‐Nanogenerator Materials for Multi‐Range Force Measurements

open access: yesAdvanced Science, EarlyView.
The multifunctional and tunable meta‐nanogenerator material system combines a mechanical metamaterial and a triboelectric nanogenerator enabling self‐powered, real‐time force sensing across application‐specific ranges. Geometrical tuning adjusts stiffness and the force sensing range, while modular integration streamlines assembly.
Roshira Premadasa   +6 more
wiley   +1 more source

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