Results 41 to 50 of about 52,339 (264)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Economic ageing and demographic change [PDF]

Vienna Yearbook of Population Research, 2007
This paper presents a generalised model of overlapping generations with economic ageing of households. Economic age is defined as a set of personal attributes such as earnings potential and tastes that are characteristic of a person’s position in the ...
Mirela Keuschnigg, Christian Keuschnigg, Dominik Grafenhofer, Christian Jaag   +3 more
doaj  

National welfare implications of regional childcare policy: A theoretical approach [PDF]

Romanian Journal of Regional Science
This study examines the effects of regional childcare policy on regional and total fertility, interregional migration, capital accumulation, and welfare.
Hiroyuki Hashimoto, Tohru Naito
doaj   +1 more source

The two sides of public debt: Intergenerational altruism and burden shifting. [PDF]

PLoS ONE, 2018
In controlled laboratory experiments with and without overlapping generations, we study the role of intergenerational altruism in public debt accumulation. Public debt is chosen by popular vote, pays for public goods, and is repaid with general taxes. We
Martin Fochmann, Florian Sachs, Abdolkarim Sadrieh, Joachim Weimann   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Population Aging, Pension Systems, and Economic Growth: Applying an Overlapping Generations Model to the Informal Sector

Asian Development Review, 2023
This paper analyzes the effects of an unfunded pension system on economic growth using an extended overlapping generations model to include the informal sector. Emerging countries usually have a more significant informal sector than advanced ones.
NAVARAT TEMSUMRIT
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Almost periodic stochastic Beverton-Holt difference equation with higher delays and with competition between overlapping generations

Nonautonomous Dynamical Systems, 2020
The paper studies the existence of an almost periodic solution of some system of stochastic Beverton-Holt equation with higher delays and with competition between overlapping generations under some reasonable assumptions.
Bezandry Paul H.
doaj   +1 more source

Economic Consequences of Population Aging for Iranian economy :Application of General Equilibrium Overlapping Generations Model [PDF]

فصلنامه پژوهش‌های اقتصادی ایران, 2019
Population aging was one of the most important concerns of the last century all over the world. In this study, in order to investigate the effect of demographic changes on some macroeconomic variables, Diamond two-stage overlapping generation model (OLG ...
Zahra Kashanian, hosein raghfar, Mir Hossein Mousavi   +2 more
doaj   +1 more source